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J Gastroenterol Hepatol:包囊性胰腺坏死经多孔道引流可改善预后

2013-11-30 MedSci MedSci原创

2013年11月刊发在J Gastroenterol Hepatol杂志上的一项回顾性研究结果显示,经内镜引流的包囊性胰腺坏死(WOPN),采用多孔道引流坏死组织可提高治疗的成功率,并且术后留置支架引流可降低胰液积液(PFC)复发。WOPN是一种包含胰腺和胰周坏死组织、具有界限分明炎性包膜结构的疾病,大多数WOPN为无菌性病变因此多采取保守治疗,无需介入治疗。介入治疗的适应症包括经抗生素治疗感染仍

2013年11月刊发在J Gastroenterol Hepatol杂志上的一项回顾性研究结果显示,经内镜引流的包囊性胰腺坏死(WOPN),采用多孔道引流坏死组织可提高治疗的成功率,并且术后留置支架引流可降低胰液积液(PFC)复发。

WOPN是一种包含胰腺和胰周坏死组织、具有界限分明炎性包膜结构的疾病,大多数WOPN为无菌性病变因此多采取保守治疗,无需介入治疗。介入治疗的适应症包括经抗生素治疗感染仍难以控制及保守治疗期间病情进一步加重。

临床上接受内镜治疗的WOPN患者的预后通常够理想。为了明确影响WOPN患者内镜治疗预后的因素,来自美国阿拉巴马大学的研究者对接受内镜治疗超过十年的WOPN患者进行了一项回顾性分析。

研究共纳入76名接受内镜治疗的患者,在传统引流组患者通过支架或鼻囊导管对坏死囊腔进行引流,多孔道引流技术(MTGT)组患者通过在胃或十二指肠上开孔进行多孔道引流。对于出现胰管离断综合征(DPDS)的患者,术后留置支架引流,以降低胰液积液(PFC)的复发。

结果显示,手术成功者有53例,MTGT组患者治疗的成功率显著高于传统引流组。经多重logistic回归分析显示,仅MTGT和减少内镜操作次数是手术成功与否的关键因素。支架留置组患者PFC的复发率显著低于无支架留置组的患者

研究者最后总结该研究带给临床以下启示:首先,对于坏死囊腔的冲洗引流,MTGT更占优势,因此治疗的短期预后较为理想;其次,尽管留置支架的拔除存在相关问题,但术后留置支架引流置可最大程度的降低PFC复发;最后,多学科密切合作可最大限度的改善患者预后。


原始出处:
Bang JY, Wilcox CM, Trevino J, Ramesh J, Peter S, Hasan M, Hawes RH, Varadarajulu S. Factors impacting treatment outcomes in the endoscopic management of walled-off pancreatic necrosis.J Gastroenterol Hepatol. 2013 Nov;28(11):1725-32.

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    2014-09-23 许安
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    2014-10-01 wolongzxh
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    2013-12-02 millore
  6. [GetPortalCommentsPageByObjectIdResponse(id=1710685, encodeId=39241e1068535, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Nov 05 05:20:00 CST 2014, time=2014-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063870, encodeId=b93420638e035, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Sep 14 09:20:00 CST 2014, time=2014-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071514, encodeId=833220e151403, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Tue Sep 23 16:20:00 CST 2014, time=2014-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1675809, encodeId=df3116e5809a8, content=<a href='/topic/show?id=7395403e580' target=_blank style='color:#2F92EE;'>#囊性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40375, encryptionId=7395403e580, topicName=囊性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=926927300775, createdName=wolongzxh, createdTime=Wed Oct 01 21:20:00 CST 2014, time=2014-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362775, encodeId=07fd1362e75e5, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Mon Dec 02 04:20:00 CST 2013, time=2013-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426569, encodeId=457b14265699b, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Mon Dec 02 04:20:00 CST 2013, time=2013-12-02, status=1, ipAttribution=)]
    2013-12-02 gwc384

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