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Lancet: 初次COVID-19感染后7个月内有相对较好的保护作用

2021-04-13 MedSci原创 MedSci原创

迫切需要了解从新冠肺炎康复的个人是否受到保护,使其不再感染SARS-CoV-2。确定再感染是典型的有症状还是无症状,再感染者是否对其他人具有传染性,以及SARS-CoV-2感染和疫苗免疫的预期持续时间

迫切需要了解从新冠肺炎康复的个人是否受到保护,使其不再感染SARS-CoV-2。确定再感染是典型的有症状还是无症状,再感染者是否对其他人具有传染性,以及SARS-CoV-2感染和疫苗免疫的预期持续时间是决定SARS-CoV-2未来传播动态的关键因素。

自2020年6月以来,国际上已有再次感染的报告,尽管这种情况仍然不常见。通过提供系统的流行病学、病毒学、免疫学和临床数据,需要进行大规模纵向队列研究和定期检测,以了解再感染率及其对政策的影响。Victoria JaneHall等进行了相关研究,目的是调查抗SARS-CoV-2抗体是否与降低有症状和无症状再感染的风险有关。文章发表在Lancet杂志。

参与者从英格兰所有地区的公立医院招募。所有在医院工作的医护人员、支持人员和行政人员只要能继续随访12个月,就有资格参加SARS-CoV-2免疫和再感染评估研究。如果参与者在登记后没有进行PCR测试,或者在2020年12月31日之后登记,或者没有足够的PCR和抗体数据进行队列分配,则被排除在外。参与者定期参加SARS-CoV-2 PCR和抗体检测(每2-4周一次),并每2周完成一次关于症状和暴露情况的问卷调查。在登记时,参与者被分配到阳性队列(抗体阳性,或以前的阳性PCR或抗体测试)或阴性队列(抗体阴性,以前没有阳性的PCR或抗体测试)。通过PCR检测,主要结果是阳性队列中的再次感染或阴性队列中的初次感染。根据病例定义(确诊的、很可能的或可能的)和症状状态,根据证据的等级,对潜在的再感染进行临床审查和分类。阴性队列中的原发感染被定义为第一次PCR阳性检测,如果与PCR检测阳性无关,则排除血清转换。使用Poisson分布的比例风险脆弱性模型来估计发病率比(IRR),以比较两组人群的感染率。

从2020年6月18日到2020年12月31日,30625参与者参加了这项研究。51名参与者退出了这项研究,4913名被排除在外,25661名参与者(有抗体和PCR 检测的关联数据)被纳入分析。数据是在2021年2月5日从所有来源提取的,包括截至2021年1月11日的数据。在8278名参与者的基线阳性队列中检测到155例感染,总共有2 047 113人天数随访。相比之下,在17383名参与者的阴性队列中,有1704名新的PCR阳性感染,共有2 971436人日随访。2020年6月至2021年1月,在阳性队列中,再感染的发病率为7.6/10万 人天数,而在阴性队列中,初次感染的发病率为57.3/10万 人天数。与PCR确认的初次感染相比,所有再感染的调整后IRR为0.159(95%CI为0·13~0·19)。初次感染到再感染的中位间隔时间在200天以上。

 2020年3月至2021年1月,根据基线队列分配,每周首次PCR检测阳性的SIREN参与者的频率

在7个月的随访后,这项大型观察性研究显示,以前感染SARS-CoV-2的大多数人平均可保护7个月不再感染SARS-CoV-2。已经确认和调查了比迄今为止全球文献报道的更多的潜在再感染,这支持了像SEREN这样的大型前瞻性队列研究的价值。这项研究支持这样一种假设,即初次感染SARS-CoV-2可在中短期内为重复感染提供高度免疫力;对症状性感染的预防水平与针对劳动年龄成年人的新许可疫苗相似。这项研究还表明,来自先前感染的免疫力对B.1.1.7变异株的再次感染具有保护作用。初次感染还降低了无症状感染和继续传播的风险;这一点特别重要,因为在英国的第一波疫情中,医疗保健被认为是持续社区传播的潜在驱动因素。

综上所述,SARS-CoV-2既往感染史与感染风险降低84%相关,初次感染后7个月观察到中间保护作用。这段时间是最小的可能影响,因为血清转换不包括在内。这项研究表明,以前感染过SARS-CoV-2的大多数人对未来的感染都能诱导有效的免疫力。该研究发现增加了这种保护也可以通过疫苗诱导免疫实现的可能性。关于抗体反应的持久性、变异挑战下的再感染率的评估以及英国引入的所有新冠肺炎疫苗的效果的进一步详细研究正在该队列中进行。

原文出处

Hall Victoria Jane,Foulkes Sarah,Charlett Andre et al. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN).[J] .Lancet, 2021, undefined: undefined.

 

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    2021-09-11 howi
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    2021-04-14 梅干儿

    三人行,必有我师。 #梅斯医学科研互助群# 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1831120, encodeId=33601831120bf, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Sep 11 18:39:02 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599155, encodeId=ffd715991551f, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ee918684940, createdName=photoman, createdTime=Thu Apr 15 14:39:02 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956751, encodeId=0342956e5154, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Wed Apr 14 00:12:05 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956836, encodeId=d20a956836d7, content=如果最终达一年,这个病毒可能会从地球上消失<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Wed Apr 14 10:32:49 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956797, encodeId=59d2956e97a7, content=明白了, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cecc5479515, createdName=ms4000001526448708, createdTime=Wed Apr 14 08:30:01 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956778, encodeId=8e0e956e7801, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/05/14/485d6988698d6dd918c9b1df896aec0f.jpg, createdBy=5fc45328463, createdName=148c3e84m19暂无昵称, createdTime=Wed Apr 14 05:27:06 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034269, encodeId=07021034269a3, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Wed Apr 14 02:39:02 CST 2021, time=2021-04-14, status=1, ipAttribution=)]
    2021-04-14 小小医者

    如果最终达一年,这个病毒可能会从地球上消失#新冠肺炎#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1831120, encodeId=33601831120bf, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Sep 11 18:39:02 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599155, encodeId=ffd715991551f, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ee918684940, createdName=photoman, createdTime=Thu Apr 15 14:39:02 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956751, encodeId=0342956e5154, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Wed Apr 14 00:12:05 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956836, encodeId=d20a956836d7, content=如果最终达一年,这个病毒可能会从地球上消失<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Wed Apr 14 10:32:49 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956797, encodeId=59d2956e97a7, content=明白了, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cecc5479515, createdName=ms4000001526448708, createdTime=Wed Apr 14 08:30:01 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956778, encodeId=8e0e956e7801, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/05/14/485d6988698d6dd918c9b1df896aec0f.jpg, createdBy=5fc45328463, createdName=148c3e84m19暂无昵称, createdTime=Wed Apr 14 05:27:06 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034269, encodeId=07021034269a3, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Wed Apr 14 02:39:02 CST 2021, time=2021-04-14, status=1, ipAttribution=)]
    2021-04-14 ms4000001526448708

    明白了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1831120, encodeId=33601831120bf, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Sep 11 18:39:02 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599155, encodeId=ffd715991551f, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ee918684940, createdName=photoman, createdTime=Thu Apr 15 14:39:02 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956751, encodeId=0342956e5154, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Wed Apr 14 00:12:05 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956836, encodeId=d20a956836d7, content=如果最终达一年,这个病毒可能会从地球上消失<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Wed Apr 14 10:32:49 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956797, encodeId=59d2956e97a7, content=明白了, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cecc5479515, createdName=ms4000001526448708, createdTime=Wed Apr 14 08:30:01 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956778, encodeId=8e0e956e7801, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/05/14/485d6988698d6dd918c9b1df896aec0f.jpg, createdBy=5fc45328463, createdName=148c3e84m19暂无昵称, createdTime=Wed Apr 14 05:27:06 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034269, encodeId=07021034269a3, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Wed Apr 14 02:39:02 CST 2021, time=2021-04-14, status=1, ipAttribution=)]
    2021-04-14 148c3e84m19暂无昵称

    学了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1831120, encodeId=33601831120bf, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Sep 11 18:39:02 CST 2021, time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599155, encodeId=ffd715991551f, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ee918684940, createdName=photoman, createdTime=Thu Apr 15 14:39:02 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956751, encodeId=0342956e5154, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Wed Apr 14 00:12:05 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956836, encodeId=d20a956836d7, content=如果最终达一年,这个病毒可能会从地球上消失<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Wed Apr 14 10:32:49 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956797, encodeId=59d2956e97a7, content=明白了, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cecc5479515, createdName=ms4000001526448708, createdTime=Wed Apr 14 08:30:01 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=956778, encodeId=8e0e956e7801, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/05/14/485d6988698d6dd918c9b1df896aec0f.jpg, createdBy=5fc45328463, createdName=148c3e84m19暂无昵称, createdTime=Wed Apr 14 05:27:06 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034269, encodeId=07021034269a3, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Wed Apr 14 02:39:02 CST 2021, time=2021-04-14, status=1, ipAttribution=)]
    2021-04-14 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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