Sci Rep：肾包膜入侵是局部透明细胞肾细胞癌的预后生物标记

2018-01-27 AlexYang MedSci原创

肾细胞膜入侵（RCI）和淋巴血管入侵（LVI）是肾细胞癌（RCC）显著的潜在预后因子。最近，有研究人员基于大规模多个群体，评估了RCI和LVI在局部透明细胞肾细胞癌中的独立的预后影响。研究包括了6849名经历了因RCC而经历根治性或者部分肾切除术的病人。研究人员通过构建统计学模型并且组合Cox比例风险回归和倾向评分匹配对RCI或LVI与复发的相关性进行了分析。为了分析RCI，研究共募集了2733名

肾细胞膜入侵（RCI）和淋巴血管入侵（LVI）是肾细胞癌（RCC）显著的潜在预后因子。最近，有研究人员基于大规模多个群体，评估了RCI和LVI在局部透明细胞肾细胞癌中的独立的预后影响。

研究包括了6849名经历了因RCC而经历根治性或者部分肾切除术的病人。研究人员通过构建统计学模型并且组合Cox比例风险回归和倾向评分匹配对RCI或LVI与复发的相关性进行了分析。为了分析RCI，研究共募集了2733名病人，其中包括了603名患有RCI的病人。为了分析LVI，研究共募集了3586名病人，其中包括了121名患有LVI的病人。研究发现，在患有RCI病人中，复发人数为75名（12.4%）；而在不患有RCI的病人中，复发人数为134名（6.3%）。在所有的统计学模型中，RCI与复发风险的增加显著相关。另外，复发在LVI病人中复发人数为29（24%），在不患有LVI病人中为207（6.0%）。另外，LVI与复发风险的增加显著的相关性仅在非调整过的单变量模型中存在，在多变量调整后的分析或者倾向评分匹配模型中不具有显著性。总之，这些发现表明了RCI可以作为局部透明细胞RCC复发的显著性风险因素。与RCI相反，LVI不能作为一个独立的预后变量。

原始出处：

U-Syn Ha， Kyu Won Lee， Jin-hyung Jung et al. Renal capsular invasion is a prognostic biomarker in localized clear cell renal cell carcinoma. Sci Rep. 09 Jan 2018.

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2018-07-30 qingting

#细胞癌#

81 0
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2018-05-26 1e145228m78(暂无匿称)

学习了.谢谢作者分享!

102 0
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2018-01-29 12498fa0m11暂无昵称

#生物标记#

70 0
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2018-01-29 chg122

#局部#

97 0
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2018-01-28 明月清辉

谢谢分享.学习了

96 0
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2018-01-28 1dd8c52fm63(暂无匿称)

了解了解.学习学习

90 0
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2018-01-28 秀红

学习了

123 0
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2018-01-28 三生有幸9135

学习一下谢谢分享

108 0
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2018-01-28 飛歌

学习了很有用不错

82 0
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2018-01-27 1e1b8538m79(暂无匿称)

不错的文章.值得拥有

103 0