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JAMA Pediatr:血清生物标志物用于婴儿急性颅内出血检测

2017-04-14 MedSci MedSci原创

使用Ziplex系统检测3种血清生物标志物和血红素可有效识别婴儿急性颅内出血

头部外伤是导致外伤死亡的主要原因之一。头部外伤的误诊,尤其是轻微外伤误诊会增加患者的次生疾病发病率和死亡率,而血清生物标志物是潜在的、提示医生颅内出血的可能性的定量定性工具。 研究人员通过多变量模型分析,考察Ziplex系统对新生儿颅内出血检测的适用性。

研究采用Ziplex系统检测的3种血清生物标记物-基质金属蛋白酶9、神经元-特性烯醇化酶、血管细胞黏附分子-1和一种临床变量-总血红素以确定该方法是否能预测婴儿急性颅内出血风险。

试验共涉及599名患儿,平均月龄4.7个月(SD 3.1),52%为男婴,78%为白人,8%为西班牙裔。对于急性颅内出血,Ziplex系统表现出了89.3%的灵敏性(95% CI 87.7-90.4)以及48.0%的特异性。阳性预测和阴性预测准确率分别为21.3%和95.6%。该模型对无创脑畸形、孤立的颅骨骨折或慢性颅内出血无特异性和敏感性。

使用Ziplex系统检测3种血清生物标志物和血红素可有效识别婴儿急性颅内出血。准确和及时识别没有外伤的婴儿颅内出血有可能降低外伤颅脑损伤的发病率和死亡率。

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    2017-10-20 feather89
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    2017-05-19 laymankey

    感谢分享一下!

    0

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    2017-04-16 Luyuxie_11
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    2017-04-14 山鸡

    很好……

    0

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