Anesthesiology：慢性疼痛患者的福音---高频脊髓电刺激

2015-08-23 MedSci MedSci原创

慢性疼痛是指持续一个月以上的疼痛，有学者将其比喻为一种不死的癌症。目前，慢性疼痛具有相当的广泛性及顽固性，然而针对慢性疼痛的治疗还不完善并且存在较多的副作用。研究人员表示，频率为10 kHz（HF10疗法）的脊髓电刺激（SCS)治疗也许能使患者的疼痛得到缓解，并且不具有传统低频SCS常出现的感觉异常等副作用。本次随机，平行，非劣性研究旨在比较SCS治疗对患者背部及腿部疼痛治疗的长期安全性

慢性疼痛是指持续一个月以上的疼痛，有学者将其比喻为一种不死的癌症。目前，慢性疼痛具有相当的广泛性及顽固性，然而针对慢性疼痛的治疗还不完善并且存在较多的副作用。研究人员表示，频率为10 kHz（HF10疗法）的脊髓电刺激（SCS)治疗也许能使患者的疼痛得到缓解，并且不具有传统低频SCS常出现的感觉异常等副作用。本次随机，平行，非劣性研究旨在比较SCS治疗对患者背部及腿部疼痛治疗的长期安全性及有效性。

本次研究共招募了198例存在背部及腿部疼痛的患者。其中，有171位患者通过了一个临时试验并且被植入了SCS系统。将出现50%或者更高的疼痛缓解而没有出现刺激相关的神经损伤的患者称为反应者（主要终点）。

结果显示，在植入SCS系统的第3个月，接受HF10疗法的患者中有84.5%为背痛反应者，有83.1%为腿痛反应者。在植入传统SCS系统的患者中，有43.8%为背痛反应者，有55.5%为腿痛反应者(P< 0.001)。反应者的相对比：背痛为1.9(95% CI,1.4-2.5)，腿痛为1.5 (95% CI, 1.2-1.9)。HF10疗法对于背部及腿部疼痛的治疗，比传统SCS治疗更具优越性，并且能持续12个月(P<0.001)。同时，接受HF10疗法的患者没有感觉异常的出现。

本研究表明：HF10疗法能够较传统SCS治疗更有效的缓解患者的背部及腿部疼痛；并且将对临床背部及腿部疼痛的管理产生显著影响。

原始出处：

Leonardo Kapural,Cong Yu,Matthew W.Doust,Bradford E.Gliner,M.S.,Ricardo Vallejo,B.Todd Sitzman,M.P.H.,Kasra Amirdelfan,Donna M.Morgan,Lora L.Brown,Thomas L.Yearwood,Richard Bundschu,Allen W.Burton,Thomas Yang,Ramsin Benyamin,Abram H.Burgher Novel 10-kHz High-frequency Therapy (HF10 Therapy) Is Superior to Traditional Low-frequency Spinal Cord Stimulation for the Treatment of Chronic Back and Leg Pain Anesthesiology. 2015 Jul 27

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2016-10-26 chenxh201314

好好拜读

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2016-09-15 1e10c84am36(暂无匿称)

文章不错，值得拜读

100 0
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2016-02-17 xiangyuzhou971

#EST#

66 0
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2016-04-11 Wechat4343a314

新方法

150 0
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2016-03-30 忠诚向上

好好学习一下

169 0
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2016-03-30 忠诚向上

好好学习一下

113 0
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2016-03-30 忠诚向上

好好学习一下

149 0
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2016-03-30 忠诚向上

好好学习一下

99 0
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2016-03-30 忠诚向上

好好学习一下

111 0
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2016-03-30 忠诚向上

好好学习一下

128 0

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