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Sci Rep：肾肿瘤CD105−/CD44−细胞具有干细胞特性并能够在体内形成恶性肿瘤

2020-04-16 AlexYang MedSci原创

肾癌癌细胞系恶性肿瘤
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透明细胞肾细胞肿瘤（ccRCC）是最常见肾癌。因ccRCC对化疗和放疗具有较强的抗性，其预后通常较差。许多研究表明癌症干细胞/肿瘤起始细胞（CSCs/TICs）与肿瘤的发展、疾病的恶化和入侵、转移以及

透明细胞肾细胞肿瘤（ccRCC）是最常见肾癌。因ccRCC对化疗和放疗具有较强的抗性，其预后通常较差。许多研究表明癌症干细胞/肿瘤起始细胞（CSCs/TICs）与肿瘤的发展、疾病的恶化和入侵、转移以及药物抗性有关。然而，从已建立的RCC细胞系基础ccRCC研究模型中分离出的CSCs/TICs的体内致瘤潜力尚未调查。

最近，有研究人员从Caki-1 RCC细胞系中分离出了CD105+、CD105-、CD44+和CD44- 以及CD44-/CD105- CD44+/CD105+和CD44-/CD105+细胞，证实了在稳定的细胞系中与干细胞表型相关多个亚群的存在。研究人员随后将分选的细胞皮下注射到NOD SCID小鼠中，并使用MRI和PET/CT对肿瘤生长进行监测。研究发现，CD105+、CD44+、CD44？、CD44-/CD105+和CD44-/CD105-（不包括CD105-或者CD44+/CD105+）植入后均观察到了肿瘤的生长。CD44-/CD105-细胞植入能够诱导肿瘤，并且与其他肿瘤相比具有更长的T1和不同的代谢模式。另外，所有的肿瘤均具有低的[18F]FDG摄取能力。CD105+和CD44-能够表达Nanog和Oct-4，而CD44-肿瘤还能额外表达内皮细胞标记CD31。

原始出处：

M. Fiedorowicz， M. I. Khan， D. Strzemecki et al. Renal carcinoma CD105？/CD44？ cells display stem-like properties in vitro and form aggressive tumors in vivo. Sci Rep. 25 Mar 2020

 

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1782684, encodeId=50c61e8268498, content=<a href='/topic/show?id=a92b425640' target=_blank style='color:#2F92EE;'>#CD10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4256, encryptionId=a92b425640, topicName=CD10)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Nov 02 22:06:57 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935487, encodeId=93b3193548ef8, content=<a href='/topic/show?id=c3264331d6' target=_blank style='color:#2F92EE;'>#CD44#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4331, encryptionId=c3264331d6, topicName=CD44)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Fri Mar 26 19:06:57 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864274, encodeId=cab918642e4b7, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Fri Jun 19 03:06:57 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025429, encodeId=daba1025429fd, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Apr 19 13:06:57 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393447, encodeId=24ee139344e10, content=<a href='/topic/show?id=866b82661c0' target=_blank style='color:#2F92EE;'>#肾肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82661, encryptionId=866b82661c0, topicName=肾肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Sat Apr 18 04:06:57 CST 2020, time=2020-04-18, status=1, ipAttribution=)]
    2020-11-02 一叶知秋

    #CD10#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1782684, encodeId=50c61e8268498, content=<a href='/topic/show?id=a92b425640' target=_blank style='color:#2F92EE;'>#CD10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4256, encryptionId=a92b425640, topicName=CD10)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Nov 02 22:06:57 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935487, encodeId=93b3193548ef8, content=<a href='/topic/show?id=c3264331d6' target=_blank style='color:#2F92EE;'>#CD44#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4331, encryptionId=c3264331d6, topicName=CD44)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Fri Mar 26 19:06:57 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864274, encodeId=cab918642e4b7, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Fri Jun 19 03:06:57 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025429, encodeId=daba1025429fd, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Apr 19 13:06:57 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393447, encodeId=24ee139344e10, content=<a href='/topic/show?id=866b82661c0' target=_blank style='color:#2F92EE;'>#肾肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82661, encryptionId=866b82661c0, topicName=肾肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Sat Apr 18 04:06:57 CST 2020, time=2020-04-18, status=1, ipAttribution=)]
    2021-03-26 ms8435843352634314

    #CD44#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1782684, encodeId=50c61e8268498, content=<a href='/topic/show?id=a92b425640' target=_blank style='color:#2F92EE;'>#CD10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4256, encryptionId=a92b425640, topicName=CD10)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Nov 02 22:06:57 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935487, encodeId=93b3193548ef8, content=<a href='/topic/show?id=c3264331d6' target=_blank style='color:#2F92EE;'>#CD44#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4331, encryptionId=c3264331d6, topicName=CD44)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Fri Mar 26 19:06:57 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864274, encodeId=cab918642e4b7, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Fri Jun 19 03:06:57 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025429, encodeId=daba1025429fd, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Apr 19 13:06:57 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393447, encodeId=24ee139344e10, content=<a href='/topic/show?id=866b82661c0' target=_blank style='color:#2F92EE;'>#肾肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82661, encryptionId=866b82661c0, topicName=肾肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Sat Apr 18 04:06:57 CST 2020, time=2020-04-18, status=1, ipAttribution=)]
    2020-06-19 qidongfanjian

    #CD4#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1782684, encodeId=50c61e8268498, content=<a href='/topic/show?id=a92b425640' target=_blank style='color:#2F92EE;'>#CD10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4256, encryptionId=a92b425640, topicName=CD10)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Nov 02 22:06:57 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935487, encodeId=93b3193548ef8, content=<a href='/topic/show?id=c3264331d6' target=_blank style='color:#2F92EE;'>#CD44#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4331, encryptionId=c3264331d6, topicName=CD44)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Fri Mar 26 19:06:57 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864274, encodeId=cab918642e4b7, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Fri Jun 19 03:06:57 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025429, encodeId=daba1025429fd, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Apr 19 13:06:57 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393447, encodeId=24ee139344e10, content=<a href='/topic/show?id=866b82661c0' target=_blank style='color:#2F92EE;'>#肾肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82661, encryptionId=866b82661c0, topicName=肾肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Sat Apr 18 04:06:57 CST 2020, time=2020-04-18, status=1, ipAttribution=)]
    2020-04-19 独孤立克

    干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1782684, encodeId=50c61e8268498, content=<a href='/topic/show?id=a92b425640' target=_blank style='color:#2F92EE;'>#CD10#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4256, encryptionId=a92b425640, topicName=CD10)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Nov 02 22:06:57 CST 2020, time=2020-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935487, encodeId=93b3193548ef8, content=<a href='/topic/show?id=c3264331d6' target=_blank style='color:#2F92EE;'>#CD44#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4331, encryptionId=c3264331d6, topicName=CD44)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Fri Mar 26 19:06:57 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864274, encodeId=cab918642e4b7, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Fri Jun 19 03:06:57 CST 2020, time=2020-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1025429, encodeId=daba1025429fd, content=干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=独孤立克, createdTime=Sun Apr 19 13:06:57 CST 2020, time=2020-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393447, encodeId=24ee139344e10, content=<a href='/topic/show?id=866b82661c0' target=_blank style='color:#2F92EE;'>#肾肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82661, encryptionId=866b82661c0, topicName=肾肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqySEUYKeYDjXJMYMrtscBNkpAnLfQZgDcdkEratcJPqS7ARJOXqllZQhCSFicErlBFbIywuoiaP0LQ/132, createdBy=012d2500132, createdName=ms5880526374914242, createdTime=Sat Apr 18 04:06:57 CST 2020, time=2020-04-18, status=1, ipAttribution=)]
    2020-04-18 ms5880526374914242

    #肾肿瘤#

    0

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肾细胞癌（简称肾癌）是泌尿系统中恶性程度较高的肿瘤，也是最常见的肿瘤之一，又称肾腺癌，占肾恶性肿瘤的80%～90%。据调查，肾细胞癌在我国泌尿生殖系统肿瘤中占第二位，仅次于膀胱肿瘤，占成人恶性肿瘤的2

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透明细胞肾细胞瘤（ccRCC）是世界上最常见和致死性泌尿系恶性肿瘤之一。ccRCC其中的一个致病驱使因子为小GTP酶Ras家族，在许多疾病中，包括ccRCC中具有分子开关的功能。在Di-Ras2家族的

Nature Cell Biology：表观遗传重塑塑造了炎症性肾癌和中性粒细胞依赖性的转移

晚期透明细胞肾细胞癌（ccRCC）经常引起全身性炎症。最近的研究表明癌细胞能够通过分泌细胞因子和化学因子重塑免疫系统。这种被称为癌细胞固有炎症的表型会引发转移性级联反应。

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