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J Periodontol:代谢综合征可增加患牙周病的风险

2015-03-13 MedSci MedSci原创

J Periodontol:代谢综合征可增加患牙周病的风险关键词:牙周病 流行病学 年龄 口腔医学 纵向研究 代谢综合征代谢综合征(MetS)以代谢紊乱为特点:腹部肥胖、血压升高(BP)、血脂异常以及高血糖。MetS会导致慢性炎症,并可提高患系统性疾病(如心血管疾病和2型糖尿病)的风险。世界范围内包括日本,MetS的患病率逐步升高。据估计,在日本40岁以上患有MetS的人群约为1070万(18.4

代谢综合征(MetS)以代谢紊乱为特点:腹部肥胖、血压升高(BP)、血脂异常以及高血糖。MetS会导致慢性炎症,并可提高患系统性疾病(如心血管疾病和2型糖尿病)的风险。世界范围内包括日本,MetS的患病率逐步升高。据估计,在日本40岁以上患有MetS的人群约为1070万(18.4%);45岁以上成人40%以上患有牙周病。


这表明,MetS可能与牙周病有相同的致病背景——氧化应激/线粒体功能障碍。患MetS的人群患牙周病的风险也大。实际上,先前的流行病学显示,MetS患者患牙周病的风险也高。然而,大多数研究是横断面研究,这就不能得出明确的因果关系。需要对MetS与牙周病的关系进行纵向研究,进一步明确MetS与牙周炎的关系。本研究的假设是MetS会增加患牙周病的风险。本研究的目的是为了确定在日本老年人群中,MetS是否与牙周病存在纵向关联。

背景:纵向流行病学研究很少有关于代谢综合征对牙周组织影响的评估。本次纵向研究的目的是为了调查日本人群中MetS是否是牙周病的一个危险因素。

方法:选自2003-2006年间有完整病例的125例日本老年患者。采用临床附着水平(CAL)在基线期以及随访期间记录患者全口牙周状况。随访期间,若有≥2颗以上的牙齿发生≥3mm的附着丧失,则认为牙周病继续发展。运用多变量泊松回归分析模型结合稳健误差方差评估MetS(由优化的日本胆固醇教育项目成人治疗标准 III所定义)和牙周病发展之间的关系。校正了患者的性别、收入、受教育程度、吸烟状况、基线期牙齿数目、基线期平均CAL、拜访牙医的方式以及刷牙频率等变量。

结果:MetS的患病率为27.6%(27/125)。校正了其他变量后,MetS受试者发生牙周病的几率约为非MetS人群的2.6倍。

结论:我们的研究结果支持我们先前关于MetS是日本老年人牙周病的危险因素这一假说。此外,还需更大、更多的人群以及更完整的信息来证实我们的发现。

原始出处:

Iwasaki M, Sato M, Minagawa K, Manz MC, Yoshihara A, Miyazaki H. Longitudinal Relationship Between Metabolic Syndrome and Periodontal Disease Among Japanese Adults Aged ≥70 Years: the Niigata Study. J Periodontol.2015 Jan 11:1-16. 

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encodeId=e4c71282223ba, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sun Mar 15 08:11:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430512, encodeId=ce091430512ef, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Mar 15 08:11:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450389, encodeId=44ff1450389d9, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Mar 15 08:11:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18242, encodeId=c0bb182424b, content=不是反过来,是二者相互影响,这里研究的是代谢综合征对牙周病的影响,还有研究牙周病对代谢综合征的影响, beContent=null, objectType=article, 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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

  2. 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    2015-07-07 feather89
  3. 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channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=ixiaochengdudu, createdTime=Fri Mar 13 19:04:00 CST 2015, time=2015-03-13, status=1, ipAttribution=)]
    2015-12-08 三三五五

    棒!

    0

  4. 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createdBy=f06c33759375, createdName=feather89, createdTime=Tue Jul 07 21:11:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45230, encodeId=94d9452303e, content=棒!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Dec 08 14:02:00 CST 2015, time=2015-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38408, encodeId=cc933840824, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 21:21:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), 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encodeId=e4c71282223ba, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sun Mar 15 08:11:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430512, encodeId=ce091430512ef, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Mar 15 08:11:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450389, encodeId=44ff1450389d9, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Mar 15 08:11:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18242, encodeId=c0bb182424b, content=不是反过来,是二者相互影响,这里研究的是代谢综合征对牙周病的影响,还有研究牙周病对代谢综合征的影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=ixiaochengdudu, createdTime=Fri Mar 13 19:04:00 CST 2015, time=2015-03-13, status=1, ipAttribution=)]
    2015-10-11 hlycom3356

    感谢作者分享

    0

  5. 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encodeId=e4c71282223ba, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sun Mar 15 08:11:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430512, encodeId=ce091430512ef, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Mar 15 08:11:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450389, encodeId=44ff1450389d9, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Mar 15 08:11:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18242, encodeId=c0bb182424b, content=不是反过来,是二者相互影响,这里研究的是代谢综合征对牙周病的影响,还有研究牙周病对代谢综合征的影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=ixiaochengdudu, createdTime=Fri Mar 13 19:04:00 CST 2015, time=2015-03-13, status=1, ipAttribution=)]
    2015-06-11 ljjj1053

    好好学习一下

    0

  6. 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channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=ixiaochengdudu, createdTime=Fri Mar 13 19:04:00 CST 2015, time=2015-03-13, status=1, ipAttribution=)]
    2015-03-15 fantasticer

    相互影响,正反皆宜

    0

  7. 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  8. 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    2015-03-13 ixiaochengdudu

    不是反过来,是二者相互影响,这里研究的是代谢综合征对牙周病的影响,还有研究牙周病对代谢综合征的影响

    0

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