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Stroke:急性基底动脉闭塞患者血管内治疗后一年结局情况

2021-11-10 MedSci原创 MedSci原创

血管内治疗对急性基底动脉闭塞患者1年功能结局的有益影响与原始研究中报告的90天结局相似。

急性基底动脉闭塞(BAO)是一种潜在的灾难性疾病,占所有缺血性卒中的1%,占大血管闭塞性(LVO)卒中的5%。尽管自2015年以来几项大型RCT试验证实了取栓治疗在前循环大血管闭塞性急性缺血性卒中中的安全性和有效性。但是,后循环取栓治疗的高级别证据仍然缺乏。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员在我国47家医院共同开展了一项急性基底动脉闭塞血管内治疗多中心临床登记研究(the EVT for Acute Basilar Artery Occlusion Study,BASILAR),这项研究是一项全国性前瞻性非随机研究,纳入了2014年1月至2019年5月接受血管内治疗或常规治疗的急性基底动脉闭塞患者。该研究旨在报告在这些患者的一年临床随访结局。

该研究的主要结局是一年时的改良Rankin量表,研究人员使用顺序Logistic回归分析评估为一般比值比,并根据预先指定的预后因素进行调整。次要结局包括一年时基于改良Rankin量表的结局分组(0-1、0-2或0-3)和全因死亡。

在最初BASILAR注册登记的829名患者中,有785名患者(94.7%)随访一年数据可用。改良Rankin量表的结果分布有利于血管内治疗而不是常规治疗(调整后的一般比值比为4.50[95%CI为2.81-7.29];P<0.001)。血管内治疗组的累积一年死亡率为54.6%,而常规治疗组为83.5%(调整后的比值比为4.36[95%CI为2.69-7.29];P<0.001)。

由此可见,血管内治疗对急性基底动脉闭塞患者1年功能结局的有益影响与原始研究中报告的90天结局相似。

原始出处:

Fengli Li.et al.One-Year Outcome After Endovascular Treatment for Acute Basilar Artery Occlusion.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.033658

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    2021-11-11 查查佳佳

    实了取栓治疗在前循环大血管闭塞性

    0

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    2021-11-11 李晓红

    基底动脉尖综合征致残率致死率极高

    0

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    2021-11-11 zhangwangwei

    太好了

    0

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    2021-11-11 452946589

    大血管闭塞还要血管内取栓

    0

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