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Lasers Med Sci:Wnt/β-catenin信号通路在激光光凝术后诱导多能干细胞衍生视网膜色素上皮细胞的恢复过程中具有重要作用

2018-10-10 MedSci MedSci原创

韩国天安市顺天乡大学附属医院眼科的Cho IH等人近日在Lasers Med Sci发表了一篇重要的研究论文。他们研究了,诱导多能干细胞分化来的视网膜色素上皮细胞(hiPSC-RPE)中的Wnt /β-catenin信号通路在激光光凝后修复过程中的作用。

韩国天安市顺天乡大学附属医院眼科的Cho IH等人近日在Lasers Med Sci发表了一篇重要的研究论文。他们研究了,诱导多能干细胞分化来的视网膜色素上皮细胞(hiPSC-RPE)中的Wnt /β-catenin信号通路在激光光凝后修复过程中的作用。

他们在从hiPSC分化产生RPE细胞后,进行激光光凝。通过β-连环蛋白的表达水平来评估激光光凝后不同时间点(第1天和第5天)Wnt /β-连环蛋白信号通路的活性。对RPE细胞进行Dickkopf-1(Dkk-1)处理和不处理,分别使用乙炔基-2'-脱氧尿苷(EdU)测定法和zonula occludens-1(ZO-1)表达分析来研究激光光凝后第5天时细胞增殖和细胞与细胞连接变化。通过实时定量聚合酶链反应(qRT-PCR)研究激光光凝后第5天Wnt基因的mRNA水平。

实验发现,激光光凝后第1天和第5天hiPSC-RPE的细胞质和细胞核中存在β-连环蛋白积累,表明Wnt /β-连环蛋白信号传导通路激活。许多EdU阳性细胞也表达β-连环蛋白,但在Dkk-1处理的激光光凝后第5天EdU阳性细胞数减少,这表明Wnt /β-连环蛋白信号传导通路介导了hiPSC-RPE增殖。在激光光凝后第5天用Dkk-1处理没有降低ZO-1的表达,表明Wnt /β-连环蛋白信号传导通路介导了hiPSC-RPE的恢复过程。在在激光光凝后第5天,Wnt2b、Wnt3、Wnt5a、Wnt7a和Wnt10b的mRNA水平增加。

因此,他们认为,Wnt /β-连环蛋白信号传导通路在激光光凝后的恢复过程中起关键作用,促进hiPSC-RPE增殖。这篇文章在阐明RPE恢复的潜在机制的同时,指出通过干预Wnt /β-连环蛋白信号传导通路可能对于视网膜退行性疾病的治疗具有潜力。

原文出处:

Cho, I.H., et al., The role of Wnt/beta-catenin signaling in the restoration of induced pluripotent stem cell-derived retinal pigment epithelium after laser photocoagulation. Lasers Med Sci, 2018.

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    2019-08-29 anminleiryan
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    2019-03-01 sunylz
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  5. 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  6. 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  7. 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    2018-10-12 orangesking

    0

  8. 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    2018-10-12 zhwj

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