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Diabetes Care:糖尿病患者发生糖尿病神经病变的危险因素!

2018-03-01 xing.T MedSci原创

由此可见,本研究为肥胖作为DPN危险因素提供了进一步的流行病学证据。此外,较低的HDL胆固醇水平和更高水平的丙酮醛,二羰基应激的标记,被确定为DPN发生发展的危险因素。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员在2型糖尿病筛查为基础的诊断后前13年期间前瞻性地研究了糖尿病多发性神经病(DPN)的发病率,并确定与DPN相关的危险因素。

研究人员在盎格鲁丹-麦语-荷兰糖尿病初级保健强化降糖研究的丹麦队列中使用密歇根神经病变筛查工具问卷(MNSIQ),得分≥4来确定DPN,纵向评估了DPN。研究人员采用调整了随机分组、性别和年龄的Cox比例风险模型评估糖尿病诊断中与DPN相关的危险因素。

在总数为1533人的队列中,1445人完成了基线MNSIQ检查,并且189人(13.1%)在基线时患有DPN。剩下的1256名无DPN受试者进入本研究(中位年龄为60.8岁[间距范围55.6-65.6],59%为男性)。13年糖尿病患者DPN累积发生率为10%。基线时年龄(风险比[HR]为1.03[95%可信区间(CI)为1-1.07])(单位=1岁)、体重(HR为1.09 [ 95%CI为1.03-1.16 ])(单位= 5公斤)、腰围(HR为1.14,95% CI为[1.05-1.24])(单位= 5厘米)、体重指数(HR为1.14 [ 95%CI为1.06-1.23 ])(单位= 2公斤/平方米)、log2丙酮醛(HR为1.45 [ 95%CI为1.12-1.89 ])(单位=加倍)、高密度脂蛋白胆固醇(HR为0.82,95%CI为[0.69-0.99])(单位= 0.25毫摩尔/升)和低密度脂蛋白胆固醇(HR 0.92 [ 95% CI 0.86;0.98 ])(单位= 0.25毫摩尔/升)与DPN发生的风险显著相关。

由此可见,本研究为肥胖作为DPN危险因素提供了进一步的流行病学证据。此外,较低的HDL胆固醇水平和更高水平的丙酮醛,二羰基应激的标记,被确定为DPN发生发展的危险因素。

原始出处:


Signe T. Andersen,et al. Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark.Diabetes Care.2018. https://doi.org/10.2337/dc17-2062

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    2018-03-06 飘飘爱

    很好

    0

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    2018-03-03 axin012
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