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Diabetes Care:脂肪肝和胰岛素抵抗与冠脉钙化相关

2012-07-31 张一宸 医学论坛网

  非酒精性脂肪肝(NAFLD)常与胰岛素抵抗(IR)并存,但二者是否与动脉粥样硬化独立相关并不明确。近期一项研究发现,脂肪肝和胰岛素抵抗均与冠状动脉钙化独立相关。研究于7月24日在线发表于《糖尿病护理》(Diabetes Care)杂志。   该研究涉及10153例韩国人群,受试者接受超声检查脂肪肝和心脏CT评估冠状动脉钙化(CAC)评分。IR定义为稳态模型胰岛素抵抗指数(HOMA-IR)≥第7

  非酒精性脂肪肝(NAFLD)常与胰岛素抵抗(IR)并存,但二者是否与动脉粥样硬化独立相关并不明确。近期一项研究发现,脂肪肝和胰岛素抵抗均与冠状动脉钙化独立相关。研究于7月24日在线发表于《糖尿病护理》(Diabetes Care)杂志。
  该研究涉及10153例韩国人群,受试者接受超声检查脂肪肝和心脏CT评估冠状动脉钙化(CAC)评分。IR定义为稳态模型胰岛素抵抗指数(HOMA-IR)≥第75百分位值;对CAC评分>0的者采用逻辑回归评估其危险比(OR)(95% CI)。
  结果显示,CAC 评分>0者有915例,与CAC 评分≤0者相比,前者代谢综合征(MeTS)组分的水平升高(血糖,血压、甘油三酯及腰围)或降低(HDL-C)(P<0.0001)。在这些人群中,55%存在脂肪肝、33.7%存在IR。脂肪肝、HOMA-IR与CAC评分>0相关,且独立于所有MetS特征、常规心血管危险因素以及既往CVD证据,IR和脂肪肝并存与CVC 评分>0相关。
   链接:Sung KC, Wild SH, Kwag HJ, Byrne CD.Fatty Liver, Insulin Resistance, and Features of Metabolic Syndrome.Diabetes Care.2012 Jul 24


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    2013-06-26 baoya
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