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Ginekol Pol:多囊卵巢综合征的女性患者的维生素D浓度与肥胖的关系

2015-02-18 MedSci MedSci原创

目的研究多囊卵巢综合症(PCOS)女性维生素D代谢浓度与荷尔蒙激素水平对出现的腹部和gynoidal型肥胖的影响。材料与方法26个PCOS女性患者(19~49岁,BMI:26.8~53.8 kg/m2),出现显著的腹部和gynoidal型肥胖者被招募作为研究对象。使用双能吸光光度法测量人体机体组分,测定空腹血清25-羟基维生素D、瘦蛋白 (来普汀)、葡萄糖、胰岛素、内环境平衡的评估模型(HOMA)



目的

研究多囊卵巢综合症(PCOS)女性维生素D代谢浓度与荷尔蒙激素水平对出现的腹部和gynoidal型肥胖的影响。

材料与方法
26个PCOS女性患者(19~49岁,BMI:26.8~53.8 kg/m2),出现显著的腹部和gynoidal型肥胖者被招募作为研究对象。使用双能吸光光度法测量人体机体组分,测定空腹血清25-羟基维生素D、瘦蛋白 (来普汀)、葡萄糖、胰岛素、内环境平衡的评估模型(HOMA)、脂质、雄激素、性激素结合球蛋白(SHGB)。

结果
发现维生素D不足2例,缺乏或者严重缺乏者12例。越肥胖的女性维生素D水平越低,腹部型肥胖的维生素D水平较gynoidal低(9.60±3.7 vs. 16.02±3.3 ng/mL, p<0.04)。在肥胖女性中,维生素D水平与gynoidal型肥胖无显著相关性,除了测定的空腹葡萄糖水平与HOMA。同时未找到与雄激素具有相关性的证据。在腹部型肥胖的女性中,维生素D水平与黄体生成素/卵泡雌激素比值(LH/FSH)和SHBG具有相关性。

结论
证明PCOS女性通常都具有维生素D缺乏。显著的腹部型肥胖组的维生素D水平较gynoidal过度型肥胖组低。在超重或肥胖的PCOS组中,维生素D与空腹葡萄糖和HOMA具有相关性。与之相关的LH/FSH比值被认为是因维生素D促使激素水平失调而致。未来的研究需要阐明腹部者与皮下肥胖者在维生素D代谢过程中的潜在的不同影响。

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