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JASN:心脏手术后儿童AKI进展的生物标志物!

2018-03-01 xing.T MedSci原创

由此可见,如果在额外的队列中进行验证,血浆IL-8可用于改善临床护理并指导AKI治疗试验的纳入标准。

随着儿童进入AKI的更高阶段,不良后果的风险急剧增加。没有可靠的方法预测住院患儿的AKI进展。近日,肾脏病领域权威杂志Journal of the American Society of Nephrology上发表一篇研究文章,研究人员旨在明确炎症和肾脏损伤的生物标志物是否能预测AKI的进展,研究人员在进行体外循环的儿童中进行了一项三中心前瞻性队列研究。

在通过血清肌酐值确定的AKI发病第一天,研究人员测定了尿液中生物标志物(尿中性粒细胞明胶酶相关载脂蛋白[NGAL]、IL-18、肾损伤分子1、肝脏脂肪酸结合蛋白[L-FABP]、白蛋白和胱抑素C)和血浆生物标志物(IL-1、IL-2、IFN-γ、IL-4、IL-6、IL-8、IL-10、IL-12、IL-13、TNF-αα、NGAL和胱抑素C)。研究人员将AKI进展定义AKI分期恶化或持续处于3期AKI(≥连续2天)。

总之,在408例患儿中有176例(43%)患儿术后发生AKI。在AKI患儿中,在AKI发病第一天,发生1期、2期和3期AKI的患者分别有145人(82.5%)、25人(14%)和6人(3.5%);28例(7%)患儿发生AKI进展。在AKI发病的第一天,17个生物标志物中有9个在AKI进展的患儿中显著高于无AKI进展的患儿。尿液中L-FABP(损伤标志物)和血浆IL-8(炎症标志物)对AKI进展有最高的区分性能:L-FABP校正的曲线下面积为0.70;95%可信区间为0.58-0.81;以及IL-8校正曲线下面积为0.80;95%可信区间为0.69-0.91。

由此可见,如果在额外的队列中进行验证,血浆IL-8可用于改善临床护理并指导AKI治疗试验的纳入标准。

原始出处:


Jason H. Greenberg,et al. Biomarkers of AKI Progression after Pediatric Cardiac Surgery.JASN,2018. http://jasn.asnjournals.org/content/early/2018/02/21/ASN.2017090989.abstract

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    2018-12-31 chenhongpeng
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    2018-06-27 lsndxfj
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    2019-01-16 hukaixun
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    2018-03-10 owlhealth

    不错耶.学习了

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1941348, encodeId=10bc194134880, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Mon Dec 31 03:38:00 CST 2018, time=2018-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779639, encodeId=2fac1e79639f9, content=<a href='/topic/show?id=956422397c' target=_blank style='color:#2F92EE;'>#AKI进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2239, encryptionId=956422397c, topicName=AKI进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Wed Jun 27 20:38:00 CST 2018, time=2018-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841195, encodeId=6498184119594, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Wed Jan 16 21:38:00 CST 2019, time=2019-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294848, encodeId=f54f29484825, content=不错耶.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Sat Mar 10 10:55:18 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341113, encodeId=647e13411136f, content=<a href='/topic/show?id=b97e223562' target=_blank style='color:#2F92EE;'>#AKI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2235, encryptionId=b97e223562, topicName=AKI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Sat Mar 03 05:38:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560715, encodeId=bafc1560e1565, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat Mar 03 05:38:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566724, encodeId=ed7a1566e246e, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sat Mar 03 05:38:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292012, encodeId=c59c292012be, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Thu Mar 01 14:59:52 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
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    2018-03-01 九九消寒

    优质资源.共同学习

    0

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