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Clinica Chimica Acta:被诊断为心血管疾病的成年人血浆酰基肉碱水平与心脏代谢危险因素的关系如何?

2020-06-24 MedSci原创 MedSci原创

心血管疾病的发展往往是无症状的。确定心脏代谢紊乱的初始指标可能有助于早期发现。本研究目的是确定血浆酰基肉碱(ACs)与心血管疾病和无心血管疾病的成年人心脏代谢危险因素之间的关系。

血管疾病的发展往往是无症状的。确定心脏代谢紊乱的初始指标可能有助于早期发现。本研究目的是确定血浆酰基肉碱(ACs)与心血管疾病和无心血管疾病的成年人心脏代谢危险因素之间的关系。

研究人员比较了健康对照组(非CVD组,n = 13)和诊断为CVD的个体(CVD组,n = 34)在人血浆中的AC分布。使用流动注射分析-串联质谱法对29个AC进行了目标分析。 AC与心脏代谢危险因素之间存在显着的直接相关性(p <0.05)。校正协变量后比较各组,发现两组之间最能区分(p <0.05)且诊断准确性“良好”的AC是肉碱[30.7(25.5-37.7)vs. 37.7(32.3-45.0) µM],短链AC:乙酰肉碱[8.9(7.4-10.2)vs. 11.9(9.2-14.4)µM]和异戊酰基肉碱[0.10(0.06-0.13)vs. 0.13(0.10-0.16)µM],以及中等链AC:己酰基肉碱[0.04(0.03-0.05)vs. 0.06(0.05–0.07)µM]和癸烯酰肉碱[0.18(0.12-0.22)vs.0.22(0.17–0.32)µM]。

这一评估有助于确定在诊断为心血管疾病的成年人心血管代谢风险相关的独特代谢特征。这些改变的代谢物有可能作为CVD早期检测的生物标志物。

原始出处:

Alexey Kukharenko,Alex Brito,Relationship between the plasma acylcarnitine profile and cardiometabolic risk factors in adults diagnosed with cardiovascular diseases

 

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    2020-08-03 windight
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