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Cell Host & Microbe:抗生素可扰乱肠道内的氧含量和纤维分解促进致病菌的生长

2016-05-06 MedSci MedSci原创

Cell Host & Microbe:抗生素可扰乱肠道内的氧含量和纤维分解促进致病菌的生长来自加州大学-戴维斯分校的一项新的研究进一步揭示了抗生素治疗的潜在危害性,研究发现抗生素可扰乱肠道内的氧水平和纤维的分解从而促进致病菌的生长繁殖。该研究成果已在线发表于Cell Host & Microbe。20世纪40年代以来抗生素的使用拯救饿无数的生命,但是抗生素耐药性的发生,以及对抗生

来自加州大学-戴维斯分校的一项新的研究进一步揭示了抗生素治疗的潜在危害性,研究发现抗生素可扰乱肠道内的氧水平和纤维的分解从而促进致病菌的生长繁殖。该研究成果已在线发表于Cell Host & Microbe。

20世纪40年代以来抗生素的使用拯救饿无数的生命,但是抗生素耐药性的发生,以及对抗生素副作用的细致探究使得我们对抗生素的使用重新进行思考。

该研究的资深作者,医学免疫学和微生物学教授Andreas Bäumler,及其同事发现给予小鼠链霉素治疗后,小鼠肠内壁致病菌的增长繁殖。此新发现有助于我们理解肠道内有益微生物如何抵抗有害微生物(如沙门氏菌),以及抗生素如何创造促进有害致病菌生长的条件来扰乱这种关系的。

抗生素使得肠道内的致病菌可以呼吸

链霉素先减少了肠道中有益微生物的量,包括梭状芽胞杆菌,它可分解植物性食物中的纤维产生有机酸(丁酸)。

丁酸是肠道细胞的一种重要资源,因为细胞可利用丁酸来吸收水分。

丁酸缺乏时,肠内壁细胞通过发酵葡萄糖产生乳酸来获得能量,随着氧水平的上高而增加,这时候有利于沙门氏菌的生长。研究人员指出:

“我们认为,沙门氏菌的毒力因子和抗生素治疗是通过相同的机制来促进致病菌的生长繁殖:降低产丁酸的梭菌来提高上皮内的氧水平,促进需氧菌沙门氏菌的生长。”

肠道中的梭状芽胞杆菌和其他有益微生物为厌氧菌,而沙门氏菌则是需氧菌,通过升高环境中的氧含量,抗生素为致病菌的生长创造了条件。

Bäumler教授说道,“本质上,抗生素使得肠道内的致病菌能够呼吸。”

研究人员指出既往研究已经表明产丁酸微生物的水平较低可促进炎症性肠道疾病的发生。

需要进一步的研究来明确本研究发现是否仅局限于低水平的丁酸与沙门氏菌之间具有关联,或者致病菌的生长是否也会影响其他可危害健康的类似机制。

原始出处:

Catharine Paddock. Antibiotics can promote 'bad' gut microbes by disrupting oxygen. MNT,Wednesday 4 May 2016.

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella, Fabian Rivera-Chávez et al., Cell Host & Microbe, doi:10.1016/j.chom.2016.03.004, published online 13 April 2016.

Additional source: CDC Antibiotics/Antimicrobial resistance, accessed 3 May 2016.

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    2017-01-28 维他命
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2079164, encodeId=acba20e91644a, content=<a href='/topic/show?id=ac4464004b7' target=_blank style='color:#2F92EE;'>#氧含量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64004, encryptionId=ac4464004b7, topicName=氧含量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Fri Nov 25 13:48:00 CST 2016, time=2016-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959609, encodeId=3b911959609eb, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jan 28 10:48:00 CST 2017, time=2017-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857374, encodeId=d955185e37402, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Mon Mar 06 01:48:00 CST 2017, time=2017-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869352, encodeId=7eb918693526b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jun 23 12:48:00 CST 2016, time=2016-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084147, encodeId=4d10208414ef3, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Oct 25 06:48:00 CST 2016, time=2016-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85604, encodeId=d01e8560418, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=229, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Thu May 12 15:36:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85231, encodeId=7f838523110, content=那到底吃不吃呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73c1706459, createdName=1de92651m76(暂无匿称), createdTime=Tue May 10 09:07:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626191, encodeId=6f11162619100, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 09:48:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-10-25 xjy02
  6. [GetPortalCommentsPageByObjectIdResponse(id=2079164, encodeId=acba20e91644a, content=<a href='/topic/show?id=ac4464004b7' target=_blank style='color:#2F92EE;'>#氧含量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64004, encryptionId=ac4464004b7, topicName=氧含量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Fri Nov 25 13:48:00 CST 2016, time=2016-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959609, encodeId=3b911959609eb, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jan 28 10:48:00 CST 2017, time=2017-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857374, encodeId=d955185e37402, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Mon Mar 06 01:48:00 CST 2017, time=2017-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869352, encodeId=7eb918693526b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jun 23 12:48:00 CST 2016, time=2016-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084147, encodeId=4d10208414ef3, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Oct 25 06:48:00 CST 2016, time=2016-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85604, encodeId=d01e8560418, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=229, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Thu May 12 15:36:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85231, encodeId=7f838523110, content=那到底吃不吃呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73c1706459, createdName=1de92651m76(暂无匿称), createdTime=Tue May 10 09:07:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626191, encodeId=6f11162619100, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 09:48:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-12 卡莲

    值得学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2079164, encodeId=acba20e91644a, content=<a href='/topic/show?id=ac4464004b7' target=_blank style='color:#2F92EE;'>#氧含量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64004, encryptionId=ac4464004b7, topicName=氧含量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Fri Nov 25 13:48:00 CST 2016, time=2016-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959609, encodeId=3b911959609eb, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jan 28 10:48:00 CST 2017, time=2017-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857374, encodeId=d955185e37402, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Mon Mar 06 01:48:00 CST 2017, time=2017-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869352, encodeId=7eb918693526b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jun 23 12:48:00 CST 2016, time=2016-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084147, encodeId=4d10208414ef3, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Oct 25 06:48:00 CST 2016, time=2016-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85604, encodeId=d01e8560418, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=229, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Thu May 12 15:36:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85231, encodeId=7f838523110, content=那到底吃不吃呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73c1706459, createdName=1de92651m76(暂无匿称), createdTime=Tue May 10 09:07:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626191, encodeId=6f11162619100, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 09:48:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-10 1de92651m76(暂无匿称)

    那到底吃不吃呢?

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2079164, encodeId=acba20e91644a, content=<a href='/topic/show?id=ac4464004b7' target=_blank style='color:#2F92EE;'>#氧含量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64004, encryptionId=ac4464004b7, topicName=氧含量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Fri Nov 25 13:48:00 CST 2016, time=2016-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959609, encodeId=3b911959609eb, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jan 28 10:48:00 CST 2017, time=2017-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857374, encodeId=d955185e37402, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Mon Mar 06 01:48:00 CST 2017, time=2017-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869352, encodeId=7eb918693526b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jun 23 12:48:00 CST 2016, time=2016-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084147, encodeId=4d10208414ef3, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Oct 25 06:48:00 CST 2016, time=2016-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85604, encodeId=d01e8560418, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=229, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Thu May 12 15:36:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85231, encodeId=7f838523110, content=那到底吃不吃呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73c1706459, createdName=1de92651m76(暂无匿称), createdTime=Tue May 10 09:07:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626191, encodeId=6f11162619100, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 09:48:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]

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