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Pediatr Infect Dis J:高剂量维生素D补充剂对健康儿童上呼吸道感染症状严重程度的影响

2020-05-31 MedSci原创 MedSci原创

观察性研究支持维生素D在减少成人和儿童病毒性上呼吸道感染(URTI)症状严重程度方面的作用。本研究评估了冬季大剂量维生素D补充(2000 IU/天)与标准剂量(400 IU/天)相比,是否能降低学龄前

观察性研究支持维生素D在减少成人和儿童病毒性上呼吸道感染(URTI)症状严重程度方面的作用。本研究评估了冬季大剂量维生素D补充(2000 IU/天)与标准剂量(400 IU/天)相比,是否能降低学龄前儿童的URTI症状严重程度。次要目标是评估大剂量补充维生素D对门诊医生就诊、急诊科(ED)就诊和抗生素处方的影响。

 

这是对加拿大多伦多市703名1-5岁健康的1-5岁儿童进行的一项多站点随机临床试验的二次分析。高剂量或标准剂量口服维生素D被随机分配1个冬季。对于每个尿毒症患者,家长根据加拿大急性呼吸道和流感量表填写症状检查表。症状严重程度、门诊就诊频率、ED就诊次数和URTI的抗生素处方在组间采用负二项式回归分析。

 

结果显示,高剂量组与标准剂量组相比,URTI症状严重程度没有降低[发病率比(IRR)=0.97;95%置信区间(CI):0.76-1.23]。高剂量维生素D没有降低门诊就诊频率(IRR=1.16;95% CI:0.84-1.60)、ED就诊频率(IRR=1.17;95% CI:0.57-2.40)或抗生素处方(IRR=1.02;95% CI:0.61-1.72)。高剂量组的血清25-羟基维生素D(48.7 ng/mL;95% CI:46.9-50.5)高于标准剂量组(36.8 ng/mL;95% CI:35.4-38.2;P <0.001)。

 

总之,与标准剂量组相比,高剂量维生素D补充剂并没有减少URTI症状严重程度、门诊就诊、ED就诊或抗生素处方。这些结果并不支持高于标准推荐剂量的维生素D补充剂用于减少儿童尿毒症症状。

 

原始出处:

 

Katrina Hueniken, Mary Aglipay, et al., Effect of High-Dose Vitamin D Supplementation on Upper Respiratory Tract Infection Symptom Severity in Healthy Children. Pediatr Infect Dis J. 2019 Jun;38(6):564-568. doi: 10.1097/INF.0000000000002225.

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    2020-07-06 feather89
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    2020-09-24 amy0550
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    2020-06-04 lovetcm

    #维生素D#怎么看

    0

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    2020-06-02 zhmscau

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