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Diabetologia:筛查工具可增加有关心血管结局的独立预后信息?

2018-04-10 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表一项关于来自密歇根神经病变筛查的三个问题集增加有关心血管结局的独立预后信息的ALTITUDE试验的研究。自我管理的密歇根神经病变筛查工具(MNSI)用于诊断糖尿病周围神经病变。研究人员探讨了MNSI是否也可以提供有关死亡风险和心血管结局的信息。 在对阿利吉仑二型糖尿病使用心肾终点(ALTITUDE)试验的阿利克仑试验的事后分析中,研究人员

近日,国际杂志 《Diabetologia》上在线发表一项关于来自密歇根神经病变筛查的三个问题集增加有关心血管结局的独立预后信息的ALTITUDE试验的研究。自我管理的密歇根神经病变筛查工具(MNSI)用于诊断糖尿病周围神经病变。研究人员探讨了MNSI是否也可以提供有关死亡风险和心血管结局的信息。 在对阿利吉仑二型糖尿病使用心肾终点(ALTITUDE)试验的阿利克仑试验的事后分析中,研究人员将8463名患有2型糖尿病和慢性肾病(CKD)和/或心血管疾病(CVD)的参与者分为独立训练(n = 3252)和验证(n = 5211)组。在训练集中,研究人员确定了与心血管复合终点(心血管死亡,复苏心脏骤停,非致命性心肌梗死/中风,心力衰竭住院)独立相关的具体问题。然后,研究人员评估这些问题在验证集中的表现。 在训练集中,有三个问题(“你的腿麻了吗?”,“你脚上有过酸痛吗?”和“你的腿在走路时受伤了吗?”)与心血管复合结果显著相关。在验证集中,对关键协变量进行多变量校正后,相对于对所有问题无阳性反应,一项或多项阳性反应(n = 3079,59.1%)与心血管复合终点风险(HR 1.54 [95%

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