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JAMA Neurol:视神经脊髓炎患者视功能障碍与视觉网络重组

2018-01-05 zhangfan MedSci原创

研究发现视神经脊髓炎综合症患者,视觉功能受损和视网膜损伤与视觉网络选择性重组有关,这一发现加强了对神经脊髓炎综合症的认识

严重的视力障碍是视神经脊髓炎综合症(NMOSD)的主要症状,近日研究人员考察了NMOSD患者的视觉网络连接性变化。

研究招募了31名水通道蛋白-4抗体阳性的NMOSD患者以及31名年龄、性别匹配志愿者,对参与者进行视功能(高对比度视力和对比度敏感度)、光学相干断层成像(乳头周围视网膜神经纤维层和神经节细胞层厚度)以及静息状态功能磁共振成像(脑网络功能连接)检查。

NMOSD患者平均年龄48.2岁,女性28人;对照组平均47.2岁,女性28人。研究发现,NMOSD患者初级和次级视觉网络选择性功能连接显著增强,初级视觉网络连接增强导致高对比度视力以及低对比度灵敏度降低,光学相干断层成像显示视网膜损伤严重。此外视神经炎史患者的视觉功能连通性显著升高(平均回归系数,50.0 vs 34.6)。

研究发现视神经脊髓炎综合症患者,视觉功能受损和视网膜损伤与视觉网络选择性重组有关,这一发现加强了对神经脊髓炎综合症的认识。

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    2018-06-30 gj0740
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    2018-07-08 xlysu
  4. 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    2018-01-16 半夏微凉

    学习了谢谢分享

    0

  6. 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content=<a href='/topic/show?id=abcd90e22c3' target=_blank style='color:#2F92EE;'>#视神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90722, encryptionId=abcd90e22c3, topicName=视神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a587885671, createdName=ms8538335253054589, createdTime=Sun Jan 07 01:28:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275723, encodeId=ea002e572345, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Jan 05 12:43:28 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275694, encodeId=a8552e56943c, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Fri Jan 05 11:26:34 CST 2018, time=2018-01-05, status=1, ipAttribution=)]
    2018-01-07 zywlvao
  8. [GetPortalCommentsPageByObjectIdResponse(id=1666958, encodeId=c2b716669582f, content=<a href='/topic/show?id=5fda90e061e' target=_blank style='color:#2F92EE;'>#视神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90706, encryptionId=5fda90e061e, topicName=视神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14db26078051, createdName=gj0740, createdTime=Sat Jun 30 08:28:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000252, encodeId=d5af200025262, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, 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content=<a href='/topic/show?id=abcd90e22c3' target=_blank style='color:#2F92EE;'>#视神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90722, encryptionId=abcd90e22c3, topicName=视神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a587885671, createdName=ms8538335253054589, createdTime=Sun Jan 07 01:28:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275723, encodeId=ea002e572345, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Jan 05 12:43:28 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275694, encodeId=a8552e56943c, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Fri Jan 05 11:26:34 CST 2018, time=2018-01-05, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1666958, encodeId=c2b716669582f, content=<a href='/topic/show?id=5fda90e061e' target=_blank style='color:#2F92EE;'>#视神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90706, encryptionId=5fda90e061e, topicName=视神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14db26078051, createdName=gj0740, createdTime=Sat Jun 30 08:28:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2000252, encodeId=d5af200025262, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, 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content=<a href='/topic/show?id=abcd90e22c3' target=_blank style='color:#2F92EE;'>#视神经脊髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90722, encryptionId=abcd90e22c3, topicName=视神经脊髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a587885671, createdName=ms8538335253054589, createdTime=Sun Jan 07 01:28:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275723, encodeId=ea002e572345, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri Jan 05 12:43:28 CST 2018, time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275694, encodeId=a8552e56943c, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Fri Jan 05 11:26:34 CST 2018, time=2018-01-05, status=1, ipAttribution=)]
    2018-01-05 半夏微凉

    学习了谢谢分享

    0

  10. 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time=2018-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275694, encodeId=a8552e56943c, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Fri Jan 05 11:26:34 CST 2018, time=2018-01-05, status=1, ipAttribution=)]
    2018-01-05 hhh678

    henhao

    0

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