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Nat Commun:中国湖南新冠密集接触者的感染性、易感性及相关危险因素

2021-03-14 haibei MedSci原创

最近,根据中国湖南1178名SARS-CoV-2潜在感染者及其15648名接触者的个人记录,研究人员估计了关键的新冠传播参数。

2019年新冠病毒(COVID-19)疫情于2019年12月在中国武汉首次发现。此次疫情由SARS-CoV-2病毒引起,并迅速在全球范围内传播,导致WHO于2020年3月11日宣布全球大流行。尽管截至2021年1月19日,全球已确认有超过9410万SARS-CoV-2感染者,但COVID-19的流行病学和自然史仍有许多未知数。

目前正在争论的一个关键问题是SARS-CoV-2感染者的感染力和易感性是否因年龄而不同。尤其是儿童在SARS-CoV-2传播中的作用尚未完全了解。大多数国家的学校在大流行的最初几个月都关闭了,因此,通报的年轻个体病例比例较低,这可能是由于出现症状的概率较低,对感染的敏感性较低,和/或相对于其他年龄组的接触机会较少。

到目前为止,这些因素中的每一个因素的重要性都很难分清。一个相关的问题是无症状传播的概率。事实上,人们经常认为,COVID-19大流行一直难以解决,是因为无症状传播的重要性。来自家庭、无家可归者收容所和护理机构等密闭环境的证据支持无症状传播的作用。然而,目前仍然缺乏对无症状传播的量化研究。

最近,根据中国湖南1178名SARS-CoV-2潜在感染者及其15648名接触者的个人记录,研究人员估计了关键的新冠传播参数。研究人员估计传染性在症状发生前1.8天达到高峰,95%的传播事件发生在症状发生前8.8天至症状发生后9.5天。大多数传播事件发生在症状发生前阶段(59.2%)。

人群对SARS-CoV-2的易感性随着年龄的增长而增加,而不同年龄组之间以及有症状和无症状个体之间的传播性并无显著差异。家庭中的接触者和接触第一代病例与较高的传播几率有关

因此,该研究结果支持儿童可以有效传播SARS-CoV-2的假设,并强调了有症状前和无症状传播如何阻碍控制工作。

 

原始出处:

Shixiong Hu et al. Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China. Nature Communications (2021). 

 

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    2021-12-27 liye789132251
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    2022-02-15 liuli5079
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    2021-03-15 ms5000000518166734

    已读,真是受益匪浅呀!

    0

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    2021-03-14 其美多吉

    学习使我成长

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1885043, encodeId=3e9e188504387, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Dec 27 04:44:33 CST 2021, time=2021-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087951, encodeId=97ba208e95133, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Tue Feb 15 23:44:33 CST 2022, time=2022-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655502, encodeId=204416555022b, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=583d24724321, createdName=charl1234575, createdTime=Thu Sep 16 05:44:33 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948390, encodeId=44c619483901f, content=<a href='/topic/show?id=a646e252819' target=_blank style='color:#2F92EE;'>#相关危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72528, encryptionId=a646e252819, topicName=相关危险因素)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/uiafWKNzZJdibyrrAR5YyVBUCbj0fhAekic1Tou5YEI9IBoJ1QrGpZylYAkiafDNofZkNHJCPTpY1HK14LvuFzD5xQ/132, createdBy=706e2500208, createdName=ms9203727104890838, createdTime=Fri Dec 10 03:44:33 CST 2021, time=2021-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460586, encodeId=7d59146058642, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59662, encryptionId=36a7596628a, topicName=易感性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6af6344165, createdName=FukaiBao, createdTime=Tue Mar 16 00:44:33 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948245, encodeId=2b82948245ce, content=已读,真是受益匪浅呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Mon Mar 15 07:54:51 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948221, encodeId=1e20948221b3, content=学习使我成长, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a1a5469069, createdName=其美多吉, createdTime=Sun Mar 14 23:30:40 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948080, encodeId=0ee794808044, content=这研究貌似可以发表在祖国大地上哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sun Mar 14 14:20:12 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029234, encodeId=e2f61029234f0, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sun Mar 14 12:44:33 CST 2021, time=2021-03-14, status=1, ipAttribution=)]
    2021-03-14 carrotlyl

    这研究貌似可以发表在祖国大地上哈哈

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1885043, encodeId=3e9e188504387, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Dec 27 04:44:33 CST 2021, time=2021-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087951, encodeId=97ba208e95133, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Tue Feb 15 23:44:33 CST 2022, time=2022-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655502, encodeId=204416555022b, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=583d24724321, createdName=charl1234575, createdTime=Thu Sep 16 05:44:33 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948390, encodeId=44c619483901f, content=<a href='/topic/show?id=a646e252819' target=_blank style='color:#2F92EE;'>#相关危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72528, encryptionId=a646e252819, topicName=相关危险因素)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/uiafWKNzZJdibyrrAR5YyVBUCbj0fhAekic1Tou5YEI9IBoJ1QrGpZylYAkiafDNofZkNHJCPTpY1HK14LvuFzD5xQ/132, createdBy=706e2500208, createdName=ms9203727104890838, createdTime=Fri Dec 10 03:44:33 CST 2021, time=2021-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460586, encodeId=7d59146058642, content=<a href='/topic/show?id=36a7596628a' target=_blank style='color:#2F92EE;'>#易感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59662, encryptionId=36a7596628a, topicName=易感性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6af6344165, createdName=FukaiBao, createdTime=Tue Mar 16 00:44:33 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948245, encodeId=2b82948245ce, content=已读,真是受益匪浅呀!, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Mon Mar 15 07:54:51 CST 2021, time=2021-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948221, encodeId=1e20948221b3, content=学习使我成长, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a1a5469069, createdName=其美多吉, createdTime=Sun Mar 14 23:30:40 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948080, encodeId=0ee794808044, content=这研究貌似可以发表在祖国大地上哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sun Mar 14 14:20:12 CST 2021, time=2021-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029234, encodeId=e2f61029234f0, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sun Mar 14 12:44:33 CST 2021, time=2021-03-14, status=1, ipAttribution=)]
    2021-03-14 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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