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Hepatology:机体孕激素或可降低特殊白介素的表达

2017-02-06 生物谷 生物谷

Hepatology上的研究报告中,来自古腾堡大学的研究人员通过研究发现,人类孕激素绒膜促性腺激素(hCG)能够通过减弱半胱天冬酶3依赖的白介素16(Caspase-3-dependent interleukin (IL)-16)释放和处理加工的过程来诱发机体的免疫抑制作用。 值得注意的是,孕期能够诱导机体出现免疫耐受性阶段,从而导致某些特殊的自身免疫疾病患者机体的临床症状得到自发性改善

图片来源:medicalxpress.com

日前,一项刊登在国际杂志Hepatology上的研究报告中,来自古腾堡大学的研究人员通过研究发现,人类孕激素绒膜促性腺激素(hCG)能够通过减弱半胱天冬酶3依赖的白介素16(Caspase-3-dependent interleukin (IL)-16)释放和处理加工的过程来诱发机体的免疫抑制作用。

值得注意的是,孕期能够诱导机体出现免疫耐受性阶段,从而导致某些特殊的自身免疫疾病患者机体的临床症状得到自发性改善,这项研究中,研究人员检测了机体肝脏中hCG引发的免疫抑制反应的机制。

研究者发现,hCG信号能够激活SIRT1,SIRT1则能够对FOXO3a分子实施脱乙酰基过程,从而诱发机体中促进细胞凋亡的基因表达水平的降低,由于缺失Caspase-3的活性,肝脏细胞中白细胞介素16(IL-16)就不会释放并进行加工了;研究者表示,血清中IL-16的水平会发生降低,而IL-16是CD4+T淋巴细胞的趋化因子,同时也能够预防T细胞迁移到损伤的肝脏细胞中。

研究者表示,来自自身免疫性肝炎、乙肝、丙肝以及非酒精性脂肪性肝炎患者机体血清中的IL-16的水平均会发生升高;在这项研究中研究者发现,机体的hCG能够通过减缓半胱天冬酶3依赖的白介素16的释放和加工过程来调节肝细胞中SIRT1/FOXO3a分子轴从而诱发机体免疫抑制的发生,同时还会伴随抑制发挥自动攻击的T细胞迁移到肝脏细胞中。

原始出处:

Caroline Steinmetz,Anubha Kashyap,Nataliya Zhivkova et al. Activation of SIRT1 by human chorionic gonadotropin exerts a therapeutic effect on hepatic injury and inflammation. Hepatology 21 January 2017.

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    2017-02-08 cqykthl

    孕期能够诱导机体出现免疫耐受性阶段,从而导致某些特殊的自身免疫疾病患者机体的临床症状得到自发性改善。

    0

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  3. [GetPortalCommentsPageByObjectIdResponse(id=174984, encodeId=d33d1e498434, content=孕期能够诱导机体出现免疫耐受性阶段,从而导致某些特殊的自身免疫疾病患者机体的临床症状得到自发性改善。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Wed Feb 08 17:32:55 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372098, encodeId=2be913e20980d, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Wed Feb 08 12:10:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385352, encodeId=575c13853528d, content=<a href='/topic/show?id=9aeb45318ed' target=_blank style='color:#2F92EE;'>#孕激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45318, encryptionId=9aeb45318ed, topicName=孕激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Wed Feb 08 12:10:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426694, encodeId=67c31426694ce, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Wed Feb 08 12:10:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=174805, encodeId=c9c51e48051f, content=这样的杂志能发上一篇就爽了,求指导。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Tue Feb 07 19:46:28 CST 2017, time=2017-02-07, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=174984, encodeId=d33d1e498434, content=孕期能够诱导机体出现免疫耐受性阶段,从而导致某些特殊的自身免疫疾病患者机体的临床症状得到自发性改善。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Wed Feb 08 17:32:55 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372098, encodeId=2be913e20980d, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Wed Feb 08 12:10:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385352, encodeId=575c13853528d, content=<a href='/topic/show?id=9aeb45318ed' target=_blank style='color:#2F92EE;'>#孕激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45318, encryptionId=9aeb45318ed, topicName=孕激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Wed Feb 08 12:10:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426694, encodeId=67c31426694ce, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Wed Feb 08 12:10:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=174805, encodeId=c9c51e48051f, content=这样的杂志能发上一篇就爽了,求指导。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Tue Feb 07 19:46:28 CST 2017, time=2017-02-07, status=1, ipAttribution=)]
    2017-02-08 gwc384
  5. [GetPortalCommentsPageByObjectIdResponse(id=174984, encodeId=d33d1e498434, content=孕期能够诱导机体出现免疫耐受性阶段,从而导致某些特殊的自身免疫疾病患者机体的临床症状得到自发性改善。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Wed Feb 08 17:32:55 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372098, encodeId=2be913e20980d, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Wed Feb 08 12:10:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385352, encodeId=575c13853528d, content=<a href='/topic/show?id=9aeb45318ed' target=_blank style='color:#2F92EE;'>#孕激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45318, encryptionId=9aeb45318ed, topicName=孕激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Wed Feb 08 12:10:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426694, encodeId=67c31426694ce, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Wed Feb 08 12:10:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=174805, encodeId=c9c51e48051f, content=这样的杂志能发上一篇就爽了,求指导。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Tue Feb 07 19:46:28 CST 2017, time=2017-02-07, status=1, ipAttribution=)]
    2017-02-07 Chongyang Zhang

    这样的杂志能发上一篇就爽了,求指导。

    0

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    我们试图探讨左炔诺孕酮宫内缓释系统(LNG-IUS)与口服孕激素(EH)治疗非典型性子宫内膜增生的疗效。进行PubMed,Scopus和中央数据库检索,到2014年8月为止,以及对相关的参考文献进行筛选。搜索仅限于人和女性的文献。本研究包括七个随机对照试验(n=766名女性)。主要观察指标为3、6、12、24个月后的治疗效果(组织学反应),不规则阴道出血率及子

AJOG:BMI对孕激素类药物预防早产疗效的影响

早产是导致新生儿死亡及短期或长期致残的主要原因,其中40%的早产发生在妊娠34周前,20%发生在32周前。妊娠34周前的早产占围产儿死亡及病率的50%。如何延长孕周以降低围产儿死亡率及病率是早产防治的关键。2003年《新英格兰医学杂志》刊登的一篇随机对照临床试验结果表明,每周注射17α-己酸羟孕酮可减少既往有早产史的单胎孕妇复发性早产的发生,降低婴儿严重并发症的发生风险。随后陆续有相关研究报道证实

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