缓释烟酸导致血小板减少，不容忽视！！

2016-04-13 佚名来宝网

根据3月25日在线发表于《美国血液学杂志》上的一封给编辑的信称，缓释烟酸与渐进性和可逆性血小板减少症有关。来自南加州大学凯克医学院的Casey O' Connell和队友们描述了四名服用烟酸缓释制剂连续20个月到9年的男性患者（平均年龄68.8岁）。所有四名患者均发展成了渐进性的血小板减少症。研究人员发现停止使用烟酸缓释剂后血小板会迅速恢复，因为在所

根据3月25日在线发表于《美国血液学杂志》上的一封给编辑的信称，缓释烟酸与渐进性和可逆性血小板减少症有关。

来自南加州大学凯克医学院的Casey O' Connell和队友们描述了四名服用烟酸缓释制剂连续20个月到9年的男性患者（平均年龄68.8岁）。所有四名患者均发展成了渐进性的血小板减少症。

研究人员发现停止使用烟酸缓释剂后血小板会迅速恢复，因为在所有四名患者中停用烟酸缓释制剂一个月内观察到了明显的症状改善。根据测定因果关系的证据级别标准，三名患者被发现具有可能性关联，而有一名患者被发现具有肯定性关联。患者按照中等剂量2250毫克/天平均连续应用59天烟酸缓释剂。136天的平均响应时间内血小板恢复了平均91.5 × 109/L。在四个乏力同时血小板减少的患者中有两个在中断烟酸缓释剂后血红蛋白具有显著改善。

“总之，烟酸缓释剂已知会导致可逆性血小板减少症，但是这一影响可能比较隐匿也比较严重，可能伴有可逆性贫血，这两种情况在具有多种医疗病症和接受相应药物治疗的患者身上都可能很容易被忽视，”作者们写道。

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2016-04-15 lingaifan

#血小板减少#

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2016-04-15 zblhy

#烟酸#

84 0
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2016-04-14 李继凯

高大上的文章

174 0
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2016-04-14 李继凯

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