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Radiology：胖不胖可能决定透明细胞肾癌患者整体生存期

2018-04-20 shaosai MedSci原创

透明细胞肾癌脂肪糖酵解
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本研究旨在验证是否男女腹腔内脏脂肪含量差异及肿瘤葡萄糖代谢能有助于预测透明细胞肾癌（RCC）的结果，并将结果发表在Radioloy上。

本研究旨在验证是否男女腹腔内脏脂肪含量差异及肿瘤葡萄糖代谢能有助于预测透明细胞肾癌（RCC）的结果，并将结果发表在Radioloy上。

本研究纳入了222例有透明细胞RCC的患者，利用CT身体脂肪被分为皮下脂肪及内脏脂肪区域（VFAs），并行全身脂肪校正来得到相对VFA（rVFA）和相对皮下脂肪区域。收集患者的39个糖酵解基因的表达特征来确定代谢的性别差异并与rVFA进行比较。分析透明细胞RCC主要突变与rVFA和肿瘤糖酵解特征的相关性。

结果为， rVFA超过30.9%的女性患者的死亡风险更高(HR：3.66 [95% CI： 1.64， 8.19]) vs 1.13 ([95% CI： 0.58， 2.18] for men， P = .028)。糖酵解基因表达在男女间分层，低rVFA和低糖酵解在19例女性患者中有较好的整体生存期(P < .001)。SETD2和BAP1突变会独特地增加女性患者肿瘤糖酵解(分别为P = .036、.001)。在高rVFA和低rVFA患者间肿瘤突变无统计学差异。

本研究表明，内脏脂肪男女差异和和肿瘤葡萄糖代谢可能会对透明细胞RCC患者提供新的风险分层系统。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=309815, encodeId=34b2309815d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Fri Apr 27 14:57:50 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378169, encodeId=55ac13e8169e5, content=<a href='/topic/show?id=c29b69004f9' target=_blank style='color:#2F92EE;'>#生存期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69004, encryptionId=c29b69004f9, topicName=生存期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun Apr 22 08:45:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307839, encodeId=5a8a30e8398e, content=不错.学习了.做笔记了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, createdName=梦想起航ing, createdTime=Sat Apr 21 08:00:36 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307637, encodeId=e77030e63760, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Apr 20 18:29:00 CST 2018, time=2018-04-20, status=1, ipAttribution=)]
    2018-04-27 1201e5c5m39暂无昵称

    学习了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=309815, encodeId=34b2309815d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Fri Apr 27 14:57:50 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378169, encodeId=55ac13e8169e5, content=<a href='/topic/show?id=c29b69004f9' target=_blank style='color:#2F92EE;'>#生存期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69004, encryptionId=c29b69004f9, topicName=生存期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun Apr 22 08:45:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307839, encodeId=5a8a30e8398e, content=不错.学习了.做笔记了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, createdName=梦想起航ing, createdTime=Sat Apr 21 08:00:36 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307637, encodeId=e77030e63760, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Apr 20 18:29:00 CST 2018, time=2018-04-20, status=1, ipAttribution=)]
    2018-04-22 仁者大医

    #生存期#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=309815, encodeId=34b2309815d7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Fri Apr 27 14:57:50 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378169, encodeId=55ac13e8169e5, content=<a href='/topic/show?id=c29b69004f9' target=_blank style='color:#2F92EE;'>#生存期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69004, encryptionId=c29b69004f9, topicName=生存期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun Apr 22 08:45:00 CST 2018, time=2018-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307839, encodeId=5a8a30e8398e, content=不错.学习了.做笔记了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, createdName=梦想起航ing, createdTime=Sat Apr 21 08:00:36 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307637, encodeId=e77030e63760, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Apr 20 18:29:00 CST 2018, time=2018-04-20, status=1, ipAttribution=)]
    2018-04-21 梦想起航ing

    不错.学习了.做笔记了.谢谢分享!

    0

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    2018-04-20 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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