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JAMA Inter Med:供体年龄及性别对输血者的影响

2017-05-01 zhangfan MedSci原创

供体年龄和性别与患者生存率无关,血液分配时不需要考虑供体年龄和性别

动物模型表明来自于年轻供体血液可能存在使衰老机体"复苏"的功能。目前至少有2项人体观测研究针对供体年龄对于患者的影响,但结论却不相同。近日研究人员针对供体的年龄与性别对输血患者生存率的影响进行研究。

研究人员收集分析了2003年至2012年瑞典和丹麦,接受自体血红细胞输血或不明献血者输血的患者的资料,采用Cox比例风险回归研究患者死亡危险比和调整后的累计死亡率差异。

结果分析包括968264接受输血的患者资料(男性550257,女性418007,平均的首次输血年龄73岁),结果表明,献血者年龄和受血者死亡呈现出"U"型关系,供血者年龄在40-49岁之间,受血者死亡率最低,极端供血年龄组导致受血者死亡风险显著上升 (<20 岁: HR, 1.12; 95% CI, 1.10-1.14; ≥70 岁:HR,1.25;95% CI,1.08-1.44),女性献血者血液导致患者死亡率也较高(HR,1.07;95% CI,1.07-1.07)。将上述结果针对患者输血次数进行线性关系调整后,风险差异仍存在,但进一步研究发现患者输血次数与死亡率之间应为非线性关系,将上述结果针对非线性关系调整后,供血者年龄及性别对输血者死亡无显著影响。

研究表明供体年龄和性别与患者生存率无关,血液分配时不需要考虑供体年龄和性别。

原文出处:


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    2018-02-18 feather85
  2. 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    2017-05-04 林3301

    第一次听说,学习了

    0

  3. 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    2017-05-03 windight
  4. 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topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed May 03 01:34:00 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192782, encodeId=bee3192e828f, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Tue May 02 08:39:31 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192646, encodeId=2ce1192646cd, content=很好,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 01 19:41:50 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192574, encodeId=28b41925e481, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 01 17:45:51 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192560, encodeId=85e41925603a, content=以后常去献血, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nen7zrXWiaG4hrGCwNshovyBgXNj5Q0vjMlbsaoXPqiaCRuibSpicXNzObwSj4ocZc1a0h2KKS4VNX50h0oN5TW3ibYP/0, createdBy=07662052030, createdName=138****8908, createdTime=Mon May 01 16:01:07 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
  5. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon May 01 23:07:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192636, encodeId=23a0192636ea, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon May 01 22:56:04 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192587, encodeId=6b7419258e79, content=学习到了,不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 01 19:41:50 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192574, encodeId=28b41925e481, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 01 17:45:51 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192560, encodeId=85e41925603a, content=以后常去献血, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nen7zrXWiaG4hrGCwNshovyBgXNj5Q0vjMlbsaoXPqiaCRuibSpicXNzObwSj4ocZc1a0h2KKS4VNX50h0oN5TW3ibYP/0, createdBy=07662052030, createdName=138****8908, createdTime=Mon May 01 16:01:07 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
    2017-05-02 dhzzm

    学习了分享了

    0

  6. 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topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed May 03 01:34:00 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192782, encodeId=bee3192e828f, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Tue May 02 08:39:31 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192646, encodeId=2ce1192646cd, content=很好,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon May 01 23:07:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192636, encodeId=23a0192636ea, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon May 01 22:56:04 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192587, encodeId=6b7419258e79, content=学习到了,不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 01 19:41:50 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192574, encodeId=28b41925e481, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 01 17:45:51 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192560, encodeId=85e41925603a, content=以后常去献血, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nen7zrXWiaG4hrGCwNshovyBgXNj5Q0vjMlbsaoXPqiaCRuibSpicXNzObwSj4ocZc1a0h2KKS4VNX50h0oN5TW3ibYP/0, createdBy=07662052030, createdName=138****8908, createdTime=Mon May 01 16:01:07 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
    2017-05-01 1ddf0692m34(暂无匿称)

    很好,了解了

    0

  7. 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topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed May 03 01:34:00 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192782, encodeId=bee3192e828f, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Tue May 02 08:39:31 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192646, encodeId=2ce1192646cd, content=很好,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon May 01 23:07:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192636, encodeId=23a0192636ea, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon May 01 22:56:04 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192587, encodeId=6b7419258e79, content=学习到了,不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 01 19:41:50 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192574, encodeId=28b41925e481, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 01 17:45:51 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192560, encodeId=85e41925603a, content=以后常去献血, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nen7zrXWiaG4hrGCwNshovyBgXNj5Q0vjMlbsaoXPqiaCRuibSpicXNzObwSj4ocZc1a0h2KKS4VNX50h0oN5TW3ibYP/0, createdBy=07662052030, createdName=138****8908, createdTime=Mon May 01 16:01:07 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
    2017-05-01 1dd8c52fm63(暂无匿称)

    了解了解

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nen7zrXWiaG4hrGCwNshovyBgXNj5Q0vjMlbsaoXPqiaCRuibSpicXNzObwSj4ocZc1a0h2KKS4VNX50h0oN5TW3ibYP/0, createdBy=07662052030, createdName=138****8908, createdTime=Mon May 01 16:01:07 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
    2017-05-01 1e1b8538m79(暂无匿称)

    学习到了,不错的文章

    0

  9. 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topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed May 03 01:34:00 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192782, encodeId=bee3192e828f, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Tue May 02 08:39:31 CST 2017, time=2017-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192646, encodeId=2ce1192646cd, content=很好,了解了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon May 01 23:07:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192636, encodeId=23a0192636ea, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon May 01 22:56:04 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192587, encodeId=6b7419258e79, content=学习到了,不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon May 01 19:41:50 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192574, encodeId=28b41925e481, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon May 01 17:45:51 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192560, encodeId=85e41925603a, content=以后常去献血, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nen7zrXWiaG4hrGCwNshovyBgXNj5Q0vjMlbsaoXPqiaCRuibSpicXNzObwSj4ocZc1a0h2KKS4VNX50h0oN5TW3ibYP/0, createdBy=07662052030, createdName=138****8908, createdTime=Mon May 01 16:01:07 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
    2017-05-01 明月清辉

    谢谢分享,学习了

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nen7zrXWiaG4hrGCwNshovyBgXNj5Q0vjMlbsaoXPqiaCRuibSpicXNzObwSj4ocZc1a0h2KKS4VNX50h0oN5TW3ibYP/0, createdBy=07662052030, createdName=138****8908, createdTime=Mon May 01 16:01:07 CST 2017, time=2017-05-01, status=1, ipAttribution=)]
    2017-05-01 138****8908

    以后常去献血

    0

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