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JAMA Intern Med:感染性心内膜炎赘生物与栓塞风险

2018-02-26 zhangfan MedSci原创

研究认为感染性心内膜炎赘生物大于10mm导致患者栓塞以及死亡风险显著增加

感染性心内膜炎是一种十分危险的疾病,死亡率高达40%,与80%的栓塞事件有关。一般认为心内膜炎赘生物>10mm是评估栓塞风险的重要指标。近日研究人员考察了心内膜炎赘生物>10mm与栓塞风险的相关性。

研究人员对2017年5月1日前的PubMed 和EMBASE相关资料进行考察,包括观察性研究或随机临床试验,关键词包括感染性心内膜炎、栓塞、赘生物大小、肺梗死、中风、脾栓塞、肾栓塞、视网膜栓塞和肠系膜栓塞的不同组合。

21个研究,总计6646名感染性心内膜炎患者以及5116名心内膜炎赘生物数据可用患者参与研究。研究发现赘生物大于10mm患者的血栓栓塞事件(OR,2.28;95% CI,1.71-3.05;P<0.001)以及死亡风险(OR,1.63;95% CI,1.13-2.35;P=0.009)显著高于赘生物小于10mm的患者。

研究认为感染性心内膜炎赘生物大于10mm导致患者栓塞以及死亡风险显著增加。

原始出处:


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    2018-02-28 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

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    2018-02-26 明月清辉

    谢谢分享.学习了

    0

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