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Diabetes Care:丙型肝炎病毒成功治疗后2型糖尿病患者血糖控制得到改善!

2017-06-29 xing.T MedSci原创

DAA为基础的HCV根除具有改善糖尿病患者的血糖控制的作用,其证据为降低平均HbA1c和减少胰岛素的使用。SVR的这些内分泌益处为所有糖尿病患者考虑抗病毒治疗提供了额外的理由。

丙型肝炎病毒(HCV)感染糖尿病有关,并可能恶化糖尿病患者的血糖控制。近日,糖尿病领域权威杂志Diabetes Care上发表了一研究文章,研究人员旨在调查采用直接作用的抗病毒药物(DAAs)根除HCV感染能否与糖尿病患者改善血糖控制相关。

研究人员通过全国退伍军人卫生保健系统确定了2435例接受了无干扰素和利巴韦林的针对HCV的DAA基础治疗的糖尿病患者。研究人员比较了获得持续病毒学应答(SVR)患者和没有获得SVR患者抗病毒治疗前一年和治疗后平均糖化血红蛋白(HbA1c)水平的变化值以及降糖药物使用情况。

在基础HbA1c升高的患者中,获得SVR患者(0.98%)接受抗病毒治疗相关的HbA1c下降要比那些持续治疗失败的患者(0.65%)要多(调整后的平均差异为0.34,P=0.02)。获得SVR患者使用降糖药物减少数量也比那些持续治疗失败的患者更多,特别是胰岛素的使用,在获得SVR的患者有大幅下降从41.3%到38%,相比于那些持续治疗失败的患者由小幅增加从49.8%到51%。

DAA为基础的HCV根除具有改善糖尿病患者的血糖控制的作用,其证据为降低平均HbA1c和减少胰岛素的使用。SVR的这些内分泌益处为所有糖尿病患者考虑抗病毒治疗提供了额外的理由。

原始出处:

Justine Hum,et al. Improvement in Glycemic Control of Type 2 Diabetes After Successful Treatment of Hepatitis C Virus.Diabetes Care 2017. https://doi.org/10.2337/dc17-0485

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  5. 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  6. 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  7. 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  8. 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  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Fri Jun 30 10:17:05 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-06-30 1dd8c52fm63(暂无匿称)

    学习啦

    0

  10. 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    2017-06-30 131****2916

    不错的文章,值得学习

    0

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