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JCEM:转性人激素治疗期间内脏脂肪和全身脂肪的变化及其对心脏代谢危险因素的影响

2021-08-21 MedSci原创 MedSci原创

过多的内脏脂肪会增加2型糖尿病和心血管疾病的风险,并受性激素的影响。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metaboli

过多的内脏脂肪会增加2型糖尿病血管疾病的风险,并受性激素的影响。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在探究内脏脂肪的变化和内脏脂肪与全身脂肪比(VAT/TBF),以及它们在激素治疗一年后血脂变化和胰岛素抵抗之间的关系。


在179名转性别女性和162名转性别男性中,研究人员通过线性回归分析评估了激素治疗前和一年后的全身和内脏脂肪变化,以及与脂质和胰岛素抵抗(HOMA-IR)之间的相关性。


在转性别女性中,全身脂肪总量增加了4.0 kg(95%CI为3.4;4.7),而内脏脂肪的数量没有变化(-2 g,95%CI为-15;11),尽管范围很大-318至+281,导致VAT/TBF比下降了17%(95%CI为15;19)。

在转性别男性中,全身脂肪减少了2.8 kg(95%CI为2.2;3.5),而内脏脂肪量没有变化(+3 g,95%CI为-10;16,范围为-372;+311),将VAT/TBF比提高14%(95%CI为10;17)。在两组中,VAT/TBF均与血脂或HOMA-IR的变化无关。
 
由此可见,转性别女性和转性别男性激素治疗导致了VAT/TBF的变化,主要是由于全身脂肪的变化所致,并且与心脏代谢危险因素的变化无关,这表明激素治疗的任何不利的心脏代谢作用不是由内脏脂肪或VAT/TBF所介导。

原始出处:

Maartje Klaver.et al.Change in visceral fat and total body fat and the effect on cardiometabolic risk factors during transgender hormone therapy.JCEM.2021.https://doi.org/10.1210/clinem/dgab616

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    2021-10-23 仁者大医
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