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BJC:CDX2对Ⅱ期结肠癌患者预后的影响

2018-11-30 MedSci MedSci原创

BJC近期发表了一篇文章,研究CDX2表达对II期结肠癌患者预后的影响。

BJC近期发表了一篇文章,研究CDX2表达对II期结肠癌患者预后的影响。

研究分析了两个无偏倚的队列,代表了2002年和2003年期间在丹麦接受手术的II期结肠癌的所有患者。利用免疫组化在肿瘤切片上评估CDX2表达情况。根据结果将患者分为三组,CDX2阳性组,CDX2中度组和CDX2阴性组,用于与临床数据进行比较。研究共纳入1157名患者。研究结果表明两个队列中CDX2表达缺失和无病生存不良具有显着关系,p ?= 0.0267和0.0118。第一个队列中,CDX2表达阴性,中度和阳性组的五年无病生存率分别为66%,72%和74%,第二个队列中分别为的62%,65%和75%。两个队列数据组合后进行多重Cox回归分析证实了CDX2对无病生存的独立预后影响。

文章最后认为,该回顾性研究对CDX2对II期结肠癌患者预后的影响进行了验证。结果验证了前瞻性试验的结果。

原始出处:

Torben Frøstrup Hansen, Sanne Kjær-Frifeldt, et al. Prognostic impact of CDX2 in stage II colon cancer: results from two nationwide cohorts. BJC. November 2018 doi: https://doi.org/10.1038/s41416-018-0285-5

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    2019-02-02 wodejia-dayu
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    2018-12-01 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1652643, encodeId=128f16526433f, content=<a href='/topic/show?id=5982442e0f' target=_blank style='color:#2F92EE;'>#CDX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4427, encryptionId=5982442e0f, topicName=CDX2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e0324309469, createdName=wodejia-dayu, createdTime=Sat Feb 02 07:15:00 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1692024, encodeId=c3d51692024c9, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Mon Feb 18 21:15:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354203, encodeId=5fff3542038d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Dec 01 21:38:25 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354080, encodeId=9ee7354080f7, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Fri Nov 30 16:32:05 CST 2018, time=2018-11-30, status=1, ipAttribution=)]
    2018-11-30 王秀

    学习了,涨知识了!

    0

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