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Front Neurosci:在年龄相关的听力损失中,维他命A、C、E和Mg++组合口服能够改善听觉阈值

2018-08-21 AlexYang MedSci原创

目前,年龄相关的听力损失(ARHL)增长速度加快,且伴随随后生活质量的下降和健康治疗的花费的增加,因此,需要新的治疗策略来减少和延迟该疾病造成的影响。最近,有研究人员调查了是否ARHL可以通过抗氧化物维他命A、C和E的自由基清除作用,加以Mg++组合使用(一个已知的有效的耳蜗血管舒张药(ACEMg)),能够减少ARHL产生的影响。研究包括了2个小组,ND组(正常饮食组)和ED组(包含上述药物组),

目前,年龄相关的听力损失(ARHL)增长速度加快,且伴随随后生活质量的下降和健康治疗的花费的增加,因此,需要新的治疗策略来减少和延迟该疾病造成的影响。最近,有研究人员调查了是否ARHL可以通过抗氧化物维他命A、C和E的自由基清除作用,加以Mg++组合使用(一个已知的有效的耳蜗血管舒张药(ACEMg)),能够减少ARHL产生的影响。

研究包括了2个小组,ND组(正常饮食组)和ED组(包含上述药物组),研究对象为3个月的大Wistar大鼠。研究人员在噪音刺激的前10天进行ED模式饲养,并在3, 6-8和12-14个月大时在 0.5, 1, 2, 4, 8, 16和32 kHz进行听觉脑干记录(ABR)。研究发现,在3个月大时,ND组和ED组没有观察到显著的差异。在6-8个月和12-14个月时,听觉阈值具有显著的增加,且在所有测试的频率中波振幅具有明显的减少,上述情况与ARHL的恶性发展一致。然而,在6-8个月大时,与ND组相比,ED组的阈值偏移在低和中等频率时显著更低,并且波振幅在所有的品率中显著更大。 在年龄最大组中,阈值偏移差异和波振幅仍旧存在,表明了ACEMg对听觉功能具有持续的保护作用。

最后,研究人员指出,他们的发现表明了口服ACEMg可作为治疗ARHL的一种有效的辅助治疗手段,从而推迟年龄相关听力损伤恶化引起的不良影响。

原始出处:

Alvarado JC, Fuentes-Santamaría V, Gabaldón-Ull MC et al. An Oral Combination of Vitamins A, C, E, and Mg++ Improves Auditory Thresholds in Age-Related Hearing Loss. Front Neurosci. 31 July 2018.

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    2018-08-23 ysjykql
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    2018-08-23 lsndxfj
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    2018-08-23 qjddjq
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    2018-08-22 AlexYang

    韩文刚,学习了!

    0

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    2018-08-21 phoebeyan520

    学习了

    0

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    2018-08-21 哈哈869

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1933449, encodeId=8f1d1933449c9, content=<a href='/topic/show?id=79654901349' target=_blank style='color:#2F92EE;'>#年龄相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49013, encryptionId=79654901349, topicName=年龄相关)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Wed Feb 06 22:57:00 CST 2019, time=2019-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1306244, encodeId=efef130624434, content=<a href='/topic/show?id=aeb639230b7' target=_blank style='color:#2F92EE;'>#听力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39230, encryptionId=aeb639230b7, topicName=听力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Thu Aug 23 02:57:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364371, encodeId=206913643e181, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Aug 23 02:57:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553602, encodeId=6481155360258, content=<a href='/topic/show?id=839e9e33475' target=_blank style='color:#2F92EE;'>#阈值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97334, encryptionId=839e9e33475, topicName=阈值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f4f14387940, createdName=qjddjq, createdTime=Thu Aug 23 02:57:00 CST 2018, time=2018-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340157, encodeId=2ece34015e17, content=韩文刚,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b2e1935437, createdName=AlexYang, createdTime=Wed Aug 22 13:10:56 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339921, encodeId=acd63399218a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Tue Aug 21 13:09:53 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339915, encodeId=27a633991524, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Tue Aug 21 12:48:09 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339909, encodeId=a12c339909c8, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Aug 21 12:20:08 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339907, encodeId=e23f33990e27, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/f3d88083d8829740786bed95c22464d1/e325f3af93bb747a620d16c209094d69.jpg, createdBy=9efb2014947, createdName=小小小麦兜, createdTime=Tue Aug 21 12:17:05 CST 2018, time=2018-08-21, status=1, ipAttribution=)]
    2018-08-21 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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    2018-08-21 小小小麦兜

    学习了

    0

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