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JAHA:多囊卵巢综合征相关的心血管并发症趋势、预测因素和结局

2022-06-18 MedSci原创 MedSci原创

PCOS女性在分娩住院期间发生先兆子痫/子痫、围产期心肌病和心力衰竭的风险更高。此外,诊断为PCOS的女性分娩住院与住院时间延长和住院费用增加有关。

多囊卵巢综合征(PCOS)女性发生妊娠相关并发症的风险增加。然而,围产期心血管并发症的数据仍然有限。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在调查美国分娩住院期间与PCOS诊断相关的心血管并发症的趋势、结局和预测因素。

研究人员使用了来自全国住院患者样本(2002-2019年)的数据。采用第九版国际疾病分类(ICD-9)或第十版国际疾病分类(ICD-10)代码识别分娩住院和PCOS诊断的患者。

该研究共确定了71 436308次加权住院分娩,其中0.3%为PCOS女性(n=195 675)。在研究期间,PCOS的患病率和PCOS患者的肥胖率有所增加。患有PCOS的女性年龄较大(中位数为31岁 vs 28岁;P<0.01),糖尿病、肥胖和血脂异常的患病率较高。在对年龄、种族和民族、合并症、保险和收入进行调整后,与无PCOS女性相比,PCOS仍然是包括先兆子痫(调整后的比值比[OR]为1.56[95%CI为1.54-1.59];P<0.01)、子痫(校正OR为1.58[95%CI为1.54-1.59];P<0.01)、围产期心肌病(校正OR为1.79[95%CI为1.49-2.13];P<0.01)和心力衰竭(校正OR为1.76[95%CI为1.27-2.45];P<0.01)在内的心血管并发症的独立预测因子。此外,PCOS女性分娩住院与住院时间延长(3天 vs 2天;P<0.01)和住院费用增加(4901美元 vs 3616美元;P<0.01)相关。

由此可见,PCOS女性在分娩住院期间发生先兆子痫/子痫、围产期心肌病和心力衰竭的风险更高。此外,诊断为PCOS的女性分娩住院与住院时间延长和住院费用增加有关。这表明孕前咨询和优化心脏代谢健康以改善孕产妇和新生儿结局的重要性。

原始出处:

Salman Zahid.et al.Trends, Predictors, and Outcomes of Cardiovascular Complications Associated With Polycystic Ovary Syndrome During Delivery Hospitalizations: A National Inpatient Sample Analysis (2002–2019).JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.025839

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    2023-04-23 丁鹏鹏
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    2022-06-19 zhaohui6731
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