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Redox Biol:二甲双胍能改善烟草和电子香烟对脑血管系统的危害吗?

2017-06-30 Emma MedSci原创

电子烟行业在过去几年增长迅速,它没有燃烧,使用电池供电装置来吸入水蒸汽,电子香烟中使用的电子液体尼古丁也可引起OS,脑缺血加剧和继发性脑损伤。而有研究表明,脑缺血损伤前后二甲双胍(MF)治疗能减轻应激并抑制炎症反应。

近期很多体内研究和体外研究报道,烟草烟雾(TS)引起血脑屏障(BBB)损害和卒中风险,与2型糖尿病(2DM)非常类似,其很大程度上与受Nrf2调节的常见关键调节因素氧化应激(OS),炎症和内源性抗氧化反应系统(ARE)有关。电子烟行业在过去几年增长迅速,它没有燃烧,使用电池供电装置来吸入水蒸汽,电子香烟中使用的电子液体尼古丁也可引起OS,脑缺血加剧和继发性脑损伤。而有研究表明,脑缺血损伤前后二甲双胍(MF)治疗能减轻应激并抑制炎症反应。

发表于Redox Biol的一篇文章报道,与TS相同,长期使用蒸汽电子烟会影响BBB完整性以及引起血管炎症,并促进脑卒中发病和缺血性脑损伤恶化。该研究小组之前就做过相关研究,在之前的研究中,MF能够促进由Nrf2的激活介导的反作用机制的激活,大大降低脑和脑血管水平的TS毒性,并保护BBB的完整性。而在这次的研究中,研究结果显示MF可以有效减少卒中的氧化应激和炎症,减轻由TS和蒸汽电子烟引起的缺血后脑损伤。该研究也为MF可作为戒烟后卒中风险水平回归正常治疗时间窗(time window)期间的预防保健药物提供了依据。

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    2018-04-10 sunylz
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    2017-07-04 日月生辉

    希望能找到改善脑血管系统危害的药!

    0

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    2017-07-03 meiliwuxian

    戒烟

    0

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    2017-07-02 mnda
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    2017-07-02 baihao215

    厉害了,有意思

    0

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Lancet Diabetes Endo:二甲双胍:走下神坛,回归降糖——REMOVAL研究揭晓

与其他传统口服降糖药相比,二甲双胍降糖效果肯定、低血糖风险小、价格适中,因而被国内外指南推荐为一线降糖药。

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