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Gut:欧洲年轻人中结直肠癌的发病率增加

2019-05-17 xing.T 网络

由此可见,欧洲年轻人CRC发病率上升,但这一趋势的原因需要进一步阐明。临床医生应该意识到这种趋势。如果趋势继续下去,可能需要重新考虑筛查指南。

50岁及以上的个体直肠癌(CRC)的发病率下降,但年轻人中出现了相反的趋势。在欧洲,缺乏年轻人中CRC发病率的数据。近日,消化病领域权威杂志Gut上发表了一篇研究文章,研究人员旨在分析欧洲50岁以下受试者的CRC发病率和死亡率的趋势。

研究人员从国家和地区癌症登记处检索了1990年至2016年期间与年龄相关的CRC发病率和死亡率的数据,且通过Joinpoint回归分析趋势,并表示为年度百分比变化。

研究人员检索了来自20个欧洲国家的1.437亿年龄在20-49岁的人群数据。其中,187918(0.13%)例患者被诊断为CRC。从2004年到2016年,在20-29岁的受试者中,CRC发病率平均每年增加7.9%。从2005年到2016年,30-39岁年龄组的年增长率为4.9%;从2004年到2016年,40-49岁年龄组的年增长率为1.6%。这种增长最早发生在20-29岁的受试者中,10-20岁的个体晚于30-39岁和40-49岁的个体。这与年龄群体现象一致。虽然在大多数欧洲国家,CRC发病率上升,但各国之间发现了一些异质性。最年轻的成年人中CRC死亡率没有显著变化,但在1990年至2016年期间每年下降1.1%,而在1990年至2009年期间,30-39岁和40-49岁的个体分别每年下降2.4%。

由此可见,欧洲年轻人CRC发病率上升,但这一趋势的原因需要进一步阐明。临床医生应该意识到这种趋势。如果趋势继续下去,可能需要重新考虑筛查指南。

原始出处:

Fanny ER Vuik.et al.Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years. Gut. 2019. http://dx.doi.org/10.1136/gutjnl-2018-317592

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    2019-05-19 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2019-05-18 txqjm

    谢谢了,学习

    0

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