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PNAS:消化道细菌与食物过敏

2014-08-26 佚名 神秘的地球

向小鼠的胃肠道引入梭菌属细菌能保护这些小鼠不受花生致敏作用的影响,这提示类似的方法可能提供食物过敏的疗法。美国儿童的食物过敏发生率在1997年到2007年之间上升了18%,而且许多研究提示近来饮食、卫生和抗生素使用的变化可能改变正常的胃肠道细菌,其方式增加了对食物过敏的易感性。 为了研究改变的胃肠道细菌对食物的免疫应答的影响,Cathryn Nagler及其同事诱导了小鼠的食物过敏原致敏。当暴

向小鼠的胃肠道引入梭菌属细菌能保护这些小鼠不受花生致敏作用的影响,这提示类似的方法可能提供食物过敏的疗法。美国儿童的食物过敏发生率在1997年到2007年之间上升了18%,而且许多研究提示近来饮食、卫生和抗生素使用的变化可能改变正常的胃肠道细菌,其方式增加了对食物过敏的易感性。

为了研究改变的胃肠道细菌对食物的免疫应答的影响,Cathryn Nagler及其同事诱导了小鼠的食物过敏原致敏。当暴露在花生过敏原中的时候,体内没有定居的细菌的无菌小鼠以及在出生时给予抗生素从而减少胃肠道细菌的小鼠比拥有正常的胃肠道细菌群的小鼠产生了针对花生的更高水平的抗体,这表明了这种细菌可能提供针对食物过敏的一定程度的防护。获得了肠道接种梭菌的无菌以及经过抗生素处理的小鼠不再表现出对花生的敏感性,这提示梭菌调控了针对花生过敏的防护。基因表达分析揭示出了梭菌诱导了细胞因子白细胞介素-22的制造,这减少了小鼠肠的渗透性,导致了更少的过敏原到达血流中。

研究人员表示,这些结果提示益生菌疗法可能预防或治疗对食物的过敏反应。

原始出处:

Andrew T. Stefka, Taylor Feehley, Prabhanshu Tripathi, Ju Qiu, Kathy McCoy, Sarkis K. Mazmanian,Melissa Y. Tjota, Goo-Young Seo, Severine Cao, Betty R. Theriault, Dionysios A. Antonopoulos,Liang Zhou, Eugene B. Chang, Yang-Xin Fu, and Cathryn R. Nagler. Commensal bacteria protect against food allergen sensitization. PNAS, August 25, 2014;  

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    2017-05-22 changjiu

    益生菌作用很多

    0

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    2015-06-09 drwjr
  3. [GetPortalCommentsPageByObjectIdResponse(id=201347, encodeId=953d20134efc, content=益生菌作用很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Mon May 22 22:06:11 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1855616, encodeId=944a185561641, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Tue Jun 09 04:53:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416657, encodeId=e2d5141665e07, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Thu Aug 28 04:53:00 CST 2014, time=2014-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464493, encodeId=b12a1464493ea, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Thu Aug 28 04:53:00 CST 2014, time=2014-08-28, status=1, ipAttribution=)]
    2014-08-28 yhy100201
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