Baidu
map

欧洲药品管理局:mRNA新冠疫苗与自身免疫性肝炎无关

2022-04-27 欧洲药品管理局 欧洲药品管理局

关注~

近日,发表于肝病领域期刊《肝病学杂志》(Journal of Hepatology)上关于《新冠疫苗可能引发一种罕见的以T细胞为介导的自身免疫性肝炎》的研究引发外界对于接种mRNA新冠疫苗后的不良反应的关注,这篇于2022331日定稿的论文在文中提及了在德国的一起个案报道,一名52岁男性接种2mRNA疫苗后出现的急性肝炎的双峰发作。

对此,欧洲药品管理局(EMA)药物警戒风险评估委员会(PRAC)48日公布结论:目前没有证据支持mRNA新冠疫苗与自身免疫性肝炎(AIH)之间存在因果关系,目前不需要更新疫苗的产品信息。欧洲药品管理局(EMA)药物警戒风险评估委员会(PRAC)是在42-7日的会议中讨论了该案例,并随后发布了该项最新纪要。

PRAC会议纪要显示,自身免疫性肝炎(AIH)是一种非常罕见的由自身免疫反应介导的慢性进行性肝脏炎症性疾病。PRAC在查阅了文献数据、上报至EudraVigilance数据库的AIH病例以及上市许可持有人提供的进一步数据,得出上述结论。

欧洲药品管理局(EMA)表示将继续密切监测任何新的情况报告,并在必要时采取适当的措施。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2113392, encodeId=fe45211339253, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0562596408, createdName=er.ying, createdTime=Tue Feb 07 10:36:41 CST 2023, time=2023-02-07, status=1, ipAttribution=辽宁省), GetPortalCommentsPageByObjectIdResponse(id=1659441, encodeId=a6641659441f7, content=<a href='/topic/show?id=7f998e468c2' target=_blank style='color:#2F92EE;'>#药品管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87468, encryptionId=7f998e468c2, topicName=药品管理)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Thu Mar 23 12:30:04 CST 2023, time=2023-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339454, encodeId=0abf133945459, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Fri Apr 29 01:30:04 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425483, encodeId=4b67142548321, content=<a href='/topic/show?id=b602630980d' target=_blank style='color:#2F92EE;'>#欧洲药品管理局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63098, encryptionId=b602630980d, topicName=欧洲药品管理局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c44f3972955, createdName=isabellayj, createdTime=Fri Apr 29 01:30:04 CST 2022, time=2022-04-29, status=1, ipAttribution=)]
    2023-02-07 er.ying 来自辽宁省

    学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2113392, encodeId=fe45211339253, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0562596408, createdName=er.ying, createdTime=Tue Feb 07 10:36:41 CST 2023, time=2023-02-07, status=1, ipAttribution=辽宁省), GetPortalCommentsPageByObjectIdResponse(id=1659441, encodeId=a6641659441f7, content=<a href='/topic/show?id=7f998e468c2' target=_blank style='color:#2F92EE;'>#药品管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87468, encryptionId=7f998e468c2, topicName=药品管理)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Thu Mar 23 12:30:04 CST 2023, time=2023-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339454, encodeId=0abf133945459, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Fri Apr 29 01:30:04 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425483, encodeId=4b67142548321, content=<a href='/topic/show?id=b602630980d' target=_blank style='color:#2F92EE;'>#欧洲药品管理局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63098, encryptionId=b602630980d, topicName=欧洲药品管理局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c44f3972955, createdName=isabellayj, createdTime=Fri Apr 29 01:30:04 CST 2022, time=2022-04-29, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2113392, encodeId=fe45211339253, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0562596408, createdName=er.ying, createdTime=Tue Feb 07 10:36:41 CST 2023, time=2023-02-07, status=1, ipAttribution=辽宁省), GetPortalCommentsPageByObjectIdResponse(id=1659441, encodeId=a6641659441f7, content=<a href='/topic/show?id=7f998e468c2' target=_blank style='color:#2F92EE;'>#药品管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87468, encryptionId=7f998e468c2, topicName=药品管理)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Thu Mar 23 12:30:04 CST 2023, time=2023-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339454, encodeId=0abf133945459, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Fri Apr 29 01:30:04 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425483, encodeId=4b67142548321, content=<a href='/topic/show?id=b602630980d' target=_blank style='color:#2F92EE;'>#欧洲药品管理局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63098, encryptionId=b602630980d, topicName=欧洲药品管理局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c44f3972955, createdName=isabellayj, createdTime=Fri Apr 29 01:30:04 CST 2022, time=2022-04-29, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2113392, encodeId=fe45211339253, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0562596408, createdName=er.ying, createdTime=Tue Feb 07 10:36:41 CST 2023, time=2023-02-07, status=1, ipAttribution=辽宁省), GetPortalCommentsPageByObjectIdResponse(id=1659441, encodeId=a6641659441f7, content=<a href='/topic/show?id=7f998e468c2' target=_blank style='color:#2F92EE;'>#药品管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87468, encryptionId=7f998e468c2, topicName=药品管理)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Thu Mar 23 12:30:04 CST 2023, time=2023-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339454, encodeId=0abf133945459, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Fri Apr 29 01:30:04 CST 2022, time=2022-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425483, encodeId=4b67142548321, content=<a href='/topic/show?id=b602630980d' target=_blank style='color:#2F92EE;'>#欧洲药品管理局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63098, encryptionId=b602630980d, topicName=欧洲药品管理局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c44f3972955, createdName=isabellayj, createdTime=Fri Apr 29 01:30:04 CST 2022, time=2022-04-29, status=1, ipAttribution=)]

相关资讯

首次!15家医院联合发现自身免疫性肝炎的新易感位点

研究发现了两个新的自身免疫性肝炎(AIH)的易感位点,对揭示自身免疫性肝炎的发病机制具有重要作用。

未成年人自身免疫性肝病的持续管理:长期的医疗成效与社会成就

未成年人自身免疫性肝病(Juvenile Autoimmune Liver Disease, JALD)是一种进行性炎症性疾病,临床多以转氨酶、免疫球蛋白G(IgG)水平升高,自身抗体阳性为主要特征。

Hepatology :上海交通大学马雄等团队发现自身免疫性肝炎的新易感位点

该研究确定了两个新基因座(CD28-CTLA4-ICOS 和 SYNPR),并表明四个基因座是自身免疫性肝炎潜在的危险因素。

Cell Death Dis:经典树突状细胞在自身免疫性肝炎中的作用

自身免疫性肝炎(AIH)是一种与先天性及适应性免疫系统相互作用的细胞群相关的坏死性炎性疾病。但经典树突状细胞(cDCs)对AIH的贡献及其潜在的机制仍知之甚少。 在AIH患者外周血中,成熟cDC的数量增加,与疾病的严重程度呈正相关。在实验性自身免疫性肝炎(EAH)中,可观察到成熟cDC在肝内积累,在外周血中也有所增加。因此,EAH小鼠骨髓来源的树突状细胞(BMDC)表现出比对照小鼠更强的促炎功能。

Dig Liver Dis: 自身免疫性肝炎患者血清免疫球蛋白G水平正常化与无移植生存期改善有关

自身免疫性肝病(AIH)是一种特殊类型的慢性肝病,被称为“自身免疫性肝病”、“自身免疫活动性慢性肝炎”。其性别、年龄分布与红斑狼疮相似,且常伴有肝外症状,甚至可见“狼疮”现象。

进展与未来机遇:中医药治疗自身免疫性肝炎

自身免疫性肝炎(AIH)是一种慢性炎症性肝病,发生在所有年龄段的个体中,女性发病率较高,其特征是高丙种球蛋白血症、血清自身抗体升高和界面性肝炎的组织学特征。AIH 的发病机制仍不清楚,仍需要深入研究。

Baidu
map
Baidu
map
Baidu
map