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为什么早上你的身体会僵硬:在晚上睡觉时,你的身体在抑制炎症。

2016-08-09 佚名 生物探索

新的研究描述了人体生物钟产生的一种蛋白质,在夜晚积极地抑制四肢的炎症通路。

发表在FASEB杂志上的新研究,描述了人体生物钟产生的一种蛋白质,在夜晚积极地抑制炎症通路。这种蛋白质称为隐花色素,已被证实有抗炎作用,并且有望用于炎症治疗,例如关节炎。

“通过了解生物钟蛋白质如何调节炎症,我们就可以利用这方面的知识开发新的治疗方法。”英国曼彻斯特大学人类发展研究所的内分泌和糖尿病研究中心的研究员Julie Gibbs博士说,“此外,通过调节药物治疗有效时间,我们可以增加药效。”

吉布斯和他的同事们从健康小鼠或者人类的关节组织中收集细胞。这些细胞称为纤维细胞样滑膜细胞,在炎症性关节炎病理学研究中是十分重要的研究对象。这些细胞有一个24小时的循环,当这个循环因为隐花色素移除而被破坏时,炎症反应加重了。这表明,隐花色素基因产物具有显著抗炎作用。为了验证这一假设,研究人员设计了一类用来激活蛋白质的药物来确认是否能够对抗炎症,结果表明的确有效。

“这项研究告诉我们,炎症通常被认为是慢性的,难以治愈的。可事实上,这个研究中,在大脑控制生理节奏的视交叉上核神经的影响下,炎症变得不那么可怕。这个研究的临床意义是深远的。”FASEB杂志的主编Thoru Pederson博士说。

原始出处:

  • Julie E. Gibbs1.
  • The circadian clock regulates inflammatory arthritis.FASEB.August 3, 2016.

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createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-10-09 ylzr123

      好文关注值得学习。赞!有待探究。

      0

    2. 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createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-09-03 李东泽

      很好,不错,以后会多学习

      0

    3. 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createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97007, encodeId=536c9e0078e, content=了解一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Aug 09 12:11:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97004, encodeId=ea7b9e00435, content=学习了,可以开辟多点药物途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-08-11 木水晶

      隐花色素,若研究真的对关节炎有效,真是解决又一大问题!

      0

    4. 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createdName=李东泽, createdTime=Sat Sep 03 07:55:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97399, encodeId=23619e39959, content=隐花色素,若研究真的对关节炎有效,真是解决又一大问题!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7gGJY7ibia1wDTTwTL7vXbqvekMBTHAsd3KZ7btXM9tnHuicI2LdxJtIiccXeDCiaTvzkwMuribZ9oHVA/0, createdBy=c7b81713099, createdName=木水晶, createdTime=Thu Aug 11 07:10:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540677, encodeId=8d0715406e797, content=<a href='/topic/show?id=be0ae30534b' target=_blank style='color:#2F92EE;'>#睡觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73053, encryptionId=be0ae30534b, topicName=睡觉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb5913283122, createdName=tsing_hit, createdTime=Thu Aug 11 01:47:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97350, encodeId=ea759e350af, content=很有用的, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/373C274CBC6CDF6BC9056B319924AB54/100, createdBy=97a01924365, createdName=正准备, createdTime=Wed Aug 10 19:02:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97081, encodeId=46699e08111, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97007, encodeId=536c9e0078e, content=了解一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Aug 09 12:11:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97004, encodeId=ea7b9e00435, content=学习了,可以开辟多点药物途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-08-11 tsing_hit
    5. 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createdName=李东泽, createdTime=Sat Sep 03 07:55:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97399, encodeId=23619e39959, content=隐花色素,若研究真的对关节炎有效,真是解决又一大问题!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7gGJY7ibia1wDTTwTL7vXbqvekMBTHAsd3KZ7btXM9tnHuicI2LdxJtIiccXeDCiaTvzkwMuribZ9oHVA/0, createdBy=c7b81713099, createdName=木水晶, createdTime=Thu Aug 11 07:10:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540677, encodeId=8d0715406e797, content=<a href='/topic/show?id=be0ae30534b' target=_blank style='color:#2F92EE;'>#睡觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73053, encryptionId=be0ae30534b, topicName=睡觉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb5913283122, createdName=tsing_hit, createdTime=Thu Aug 11 01:47:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97350, encodeId=ea759e350af, content=很有用的, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/373C274CBC6CDF6BC9056B319924AB54/100, createdBy=97a01924365, createdName=正准备, createdTime=Wed Aug 10 19:02:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97081, encodeId=46699e08111, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97007, encodeId=536c9e0078e, content=了解一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Aug 09 12:11:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97004, encodeId=ea7b9e00435, content=学习了,可以开辟多点药物途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-08-10 正准备

      很有用的

      0

    6. 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encryptionId=be0ae30534b, topicName=睡觉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb5913283122, createdName=tsing_hit, createdTime=Thu Aug 11 01:47:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97350, encodeId=ea759e350af, content=很有用的, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/373C274CBC6CDF6BC9056B319924AB54/100, createdBy=97a01924365, createdName=正准备, createdTime=Wed Aug 10 19:02:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97081, encodeId=46699e08111, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97007, encodeId=536c9e0078e, content=了解一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Aug 09 12:11:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97004, encodeId=ea7b9e00435, content=学习了,可以开辟多点药物途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-08-09 忠诚向上

      好好学习

      0

    7. 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encryptionId=be0ae30534b, topicName=睡觉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb5913283122, createdName=tsing_hit, createdTime=Thu Aug 11 01:47:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97350, encodeId=ea759e350af, content=很有用的, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/373C274CBC6CDF6BC9056B319924AB54/100, createdBy=97a01924365, createdName=正准备, createdTime=Wed Aug 10 19:02:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97081, encodeId=46699e08111, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97007, encodeId=536c9e0078e, content=了解一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Aug 09 12:11:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97004, encodeId=ea7b9e00435, content=学习了,可以开辟多点药物途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-08-09 doctorJiangchao

      继续关注

      0

    8. [GetPortalCommentsPageByObjectIdResponse(id=142607, encodeId=4a1914260ec0, content=好文关注值得学习。赞!有待探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Oct 09 13:17:40 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110107, encodeId=3cfc11010e7e, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:55:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97399, encodeId=23619e39959, content=隐花色素,若研究真的对关节炎有效,真是解决又一大问题!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7gGJY7ibia1wDTTwTL7vXbqvekMBTHAsd3KZ7btXM9tnHuicI2LdxJtIiccXeDCiaTvzkwMuribZ9oHVA/0, createdBy=c7b81713099, createdName=木水晶, createdTime=Thu Aug 11 07:10:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540677, encodeId=8d0715406e797, content=<a href='/topic/show?id=be0ae30534b' target=_blank style='color:#2F92EE;'>#睡觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73053, encryptionId=be0ae30534b, topicName=睡觉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb5913283122, createdName=tsing_hit, createdTime=Thu Aug 11 01:47:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97350, encodeId=ea759e350af, content=很有用的, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/373C274CBC6CDF6BC9056B319924AB54/100, createdBy=97a01924365, createdName=正准备, createdTime=Wed Aug 10 19:02:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97081, encodeId=46699e08111, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97007, encodeId=536c9e0078e, content=了解一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Aug 09 12:11:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97004, encodeId=ea7b9e00435, content=学习了,可以开辟多点药物途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-08-09 doctorJiangchao

      继续学习

      0

    9. [GetPortalCommentsPageByObjectIdResponse(id=142607, encodeId=4a1914260ec0, content=好文关注值得学习。赞!有待探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Oct 09 13:17:40 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110107, encodeId=3cfc11010e7e, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:55:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97399, encodeId=23619e39959, content=隐花色素,若研究真的对关节炎有效,真是解决又一大问题!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7gGJY7ibia1wDTTwTL7vXbqvekMBTHAsd3KZ7btXM9tnHuicI2LdxJtIiccXeDCiaTvzkwMuribZ9oHVA/0, createdBy=c7b81713099, createdName=木水晶, createdTime=Thu Aug 11 07:10:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540677, encodeId=8d0715406e797, content=<a href='/topic/show?id=be0ae30534b' target=_blank style='color:#2F92EE;'>#睡觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73053, encryptionId=be0ae30534b, topicName=睡觉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb5913283122, createdName=tsing_hit, createdTime=Thu Aug 11 01:47:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97350, encodeId=ea759e350af, content=很有用的, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/373C274CBC6CDF6BC9056B319924AB54/100, createdBy=97a01924365, createdName=正准备, createdTime=Wed Aug 10 19:02:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97081, encodeId=46699e08111, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97007, encodeId=536c9e0078e, content=了解一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Aug 09 12:11:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97004, encodeId=ea7b9e00435, content=学习了,可以开辟多点药物途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-08-09 1dd8c52fm63(暂无匿称)

      了解一下!

      0

    10. [GetPortalCommentsPageByObjectIdResponse(id=142607, encodeId=4a1914260ec0, content=好文关注值得学习。赞!有待探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Oct 09 13:17:40 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110107, encodeId=3cfc11010e7e, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:55:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97399, encodeId=23619e39959, content=隐花色素,若研究真的对关节炎有效,真是解决又一大问题!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7gGJY7ibia1wDTTwTL7vXbqvekMBTHAsd3KZ7btXM9tnHuicI2LdxJtIiccXeDCiaTvzkwMuribZ9oHVA/0, createdBy=c7b81713099, createdName=木水晶, createdTime=Thu Aug 11 07:10:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540677, encodeId=8d0715406e797, content=<a href='/topic/show?id=be0ae30534b' target=_blank style='color:#2F92EE;'>#睡觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73053, encryptionId=be0ae30534b, topicName=睡觉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb5913283122, createdName=tsing_hit, createdTime=Thu Aug 11 01:47:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97350, encodeId=ea759e350af, content=很有用的, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/373C274CBC6CDF6BC9056B319924AB54/100, createdBy=97a01924365, createdName=正准备, createdTime=Wed Aug 10 19:02:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97081, encodeId=46699e08111, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:30:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97065, encodeId=50469e065e5, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97066, encodeId=e6c39e0661d, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 09 18:23:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97007, encodeId=536c9e0078e, content=了解一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Aug 09 12:11:00 CST 2016, time=2016-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97004, encodeId=ea7b9e00435, content=学习了,可以开辟多点药物途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Tue Aug 09 11:41:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
      2016-08-09 明崖

      学习了,可以开辟多点药物途径

      0

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