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Lancet HIV:HIV感染人群肿瘤、心肌梗塞、终末期肝病及肾病风险因素研究

2019-01-23 zhangfan MedSci原创

研究认为,HIV感染人群非HIV相关肿瘤、心肌梗塞、终末期肝病及肾病的主要风险因素与一般人群相同,对相应风险因素采取必要的干预措施有助于降低HIV感染人群的并发症风险

HIV感染者其非HIV相关肿瘤、心肌梗塞、终末期肝病和肾病的负担增加,近日研究人员就HIV感染者的特异性风险因素进行了考察。

研究人员考察了2000-14年间,美国及加拿大相关HIV感染者资料,肿瘤、心肌梗塞、终末期肝病和肾病的传统危险因素包括吸烟、高血压、总胆固醇升高、II型糖尿病、肾损伤 (4期慢性肾病)、丙型肝炎病毒和乙型肝炎病毒感染。与艾滋病相关的危险因素是CD4计数低(每μ1<200个细胞)、可检测的血浆HIV RNA(>400个拷贝/ml)和临床艾滋病诊断史。

参与研究的HIV感染人群中,非HIV相关肿瘤、心肌梗塞、终末期肝病以及终末期肾病的患者分别有1405例、345例、387例以及255例,HIV男性感染者占80%。研究发现,戒烟可降低24%的肿瘤风险以及37%的心肌梗塞风险。降低总胆固醇和保持健康的对降低心肌梗死风险的贡献分别为44%和42%;HCV感染导致了33%的终末期肝病;高血压、高胆固醇、血浆HIV RNA以及低CD4细胞计数对终末期肾病的贡献分别为39%、22%、19%以及13%。

研究认为,HIV感染人群非HIV相关肿瘤、心肌梗塞、终末期肝病及肾病的主要风险因素与一般人群相同,对相应风险因素采取必要的干预措施有助于降低HIV感染人群的并发症风险。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1693482, encodeId=7ab61693482d6, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Thu Feb 07 23:32:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829933, encodeId=b41b182993359, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Feb 26 05:32:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359841, encodeId=4a2535984136, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sat Feb 02 21:16:46 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359735, encodeId=e30d359e357f, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Feb 01 09:50:58 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-02-26 howi
  3. [GetPortalCommentsPageByObjectIdResponse(id=1693482, encodeId=7ab61693482d6, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Thu Feb 07 23:32:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829933, encodeId=b41b182993359, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Feb 26 05:32:00 CST 2019, time=2019-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359841, encodeId=4a2535984136, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sat Feb 02 21:16:46 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359735, encodeId=e30d359e357f, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Feb 01 09:50:58 CST 2019, time=2019-02-01, status=1, ipAttribution=)]
    2019-02-02 衣带渐宽

    学习

    0

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    2019-02-01 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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