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Nature:警惕!研究发现常用药有助于刺激抗生素耐药性

2018-03-27 Lily 来宝网

新的研究表明,四分之一以上的非抗生素药物会抑制人肠道细菌的生长,并可能导致抗生素耐药性。而很多抗生素会影响许多种类肠道微生物的平衡。但非抗生素药物对肠道细菌的影响尚不清楚。

【研究发现,普通药物可能有助于刺激抗生素耐药性】新的研究表明,四分之一以上的非抗生素药物会抑制人肠道细菌的生长,并可能导致抗生素耐药性。而很多抗生素会影响许多种类肠道微生物的平衡。但非抗生素药物对肠道细菌的影响尚不清楚。

德国欧洲分子生物学实验室的研究人员对40种肠道细菌进行了大约1000种药物的测试。在923种非抗生素测试中,250种影响了至少一种肠道细菌的生长。

研究人员表示:“如此之多的无关药物会对肠道微生物造成间接伤害,这是令人惊讶的。而且,调查数据显示实际数字可能更高。”

肠道细菌组成的改变有助于药物副作用,但也可能是药物有益作用的一部分。“我们还不知道这些药物是如何针对微生物的,这些效应是如何在人类宿主中表现出来的,以及临床结果如何,我们需要仔细研究这些关系,因为这些知识可以极大地提高我们对现有药物的理解和有效性。”

不过,这一发现打开了一种令人担忧的可能性,即非抗生素药物可能会导致抗生素耐药性。

考虑到我们一生中服用了许多非抗生素药物,这是很可怕的,并非所有药物都会影响肠道细菌,并非所有的耐药性都会普遍存在。在某些情况下,对特定非抗生素的耐药性会引发对特定抗生素的敏感性,从而为设计最佳的药物组合开辟道路。”

原始出处:

Lisa Maier, Mihaela Pruteanu, Michael Kuhn, et al. Extensive impact of non-antibiotic drugs on human gut bacteria. Nature, 2018, doi:10.1038/nature25979.

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    2018-04-14 liye789132251
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    2018-03-28 131****1460

    学习了受益匪浅

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    2018-03-27 12223725m18暂无昵称

    非抗生素药物可能会导致抗生素耐药性.考虑到我们一生中服用了许多非抗生素药物.这是很可怕的

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    2018-03-27 sunfeifeiyang

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