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J Periodontal Res：LncRNA-01126通过MEK/ERK信号通路抑制人牙周膜细胞迁移

2020-04-03 lishiting MedSci原创

lncRNAPDLC
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越来越多的研究显示，长非编码RNAs (lncRNAs)是牙周炎进展关键的调节分子。这篇研究的目的是为了评估lncRNA-01126在牙周炎进展中的生物学作用和机制。

越来越多的研究显示，长非编码RNAs (lncRNAs)是牙周炎进展关键的调节分子。这篇研究的目的是为了评估lncRNA-01126在牙周炎进展中的生物学作用和机制。

研究通过RT-qPCR检测牙龈组织以及人牙周膜细胞(hPDLCs)中lncRNA-01126的表达水平。在hPDLCs中敲除或过表达lncRNA-01126后进行细胞迁移实验。通过CCK-8、划痕实验、transwell和流式细胞仪检测评估lncRNA-01126在牙周炎进展中的功能。最后，通过WB检测相关信号通路。

LncRNA列阵结果发现，lncRNA-01126是牙周炎患者中表达最为显著的lncRNA。LncRNA-01126在牙周炎小鼠的牙龈组织和施以牙龈卟啉单胞菌脂多糖(LPS-PG)刺激的hPDLCs中明显增加。此外，体外实验显示，lncRNA-01126通过MEK/ERK信号通路显著抑制hPDLCs的迁移。

结论：LncRNA-01126通过MEK/ERK信号通路抑制hPDLCs的迁移。

原始出处：

Yiting Zhu， Rongshuang Ai， et al. LncRNA-01126 Inhibits the Migration of Human Periodontal Ligament Cells Through MEK/ERK Signaling Pathway. J Periodontal Res.， 2020 Apr 2[Online ahead of print]

 

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    2021-03-11 ms8888626721583891

    #迁移#

    0

  2. 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    2020-10-21 naiwu77

    #MEK#

    0

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    2020-09-27 chenlianhui

    #ERK#

    0

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time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529594, encodeId=8794152959434, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Apr 05 13:07:59 CST 2020, time=2020-04-05, status=1, ipAttribution=)]
    2020-06-10 仁医06

    #牙周膜细胞#

    0

  5. 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time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529594, encodeId=8794152959434, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Apr 05 13:07:59 CST 2020, time=2020-04-05, status=1, ipAttribution=)]
    2020-10-10 yanjie6253_56072842

    #CRN#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1640984, encodeId=2d18164098466, content=<a href='/topic/show?id=7c99939e3fd' target=_blank style='color:#2F92EE;'>#迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93973, encryptionId=7c99939e3fd, topicName=迁移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d37c22750496, createdName=ms8888626721583891, createdTime=Thu Mar 11 02:07:59 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943909, encodeId=e0b1194390941, content=<a href='/topic/show?id=d2af1152597' target=_blank style='color:#2F92EE;'>#MEK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11525, encryptionId=d2af1152597, topicName=MEK)], attachment=null, authenticateStatus=null, createdAvatar=, 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encodeId=2d45130192397, content=<a href='/topic/show?id=b469109e41d' target=_blank style='color:#2F92EE;'>#lncRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10974, encryptionId=b469109e41d, topicName=lncRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Sun Apr 05 13:07:59 CST 2020, time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451211, encodeId=25c11451211ff, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sun Apr 05 13:07:59 CST 2020, time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529594, encodeId=8794152959434, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Apr 05 13:07:59 CST 2020, time=2020-04-05, status=1, ipAttribution=)]
    2020-12-20 feather89

    #PE#

    0

  7. 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time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529594, encodeId=8794152959434, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Apr 05 13:07:59 CST 2020, time=2020-04-05, status=1, ipAttribution=)]
    2020-12-17 xqptu

    #牙周膜#

    0

  8. 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time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529594, encodeId=8794152959434, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Apr 05 13:07:59 CST 2020, time=2020-04-05, status=1, ipAttribution=)]
    2020-04-05 xzw113

    #lncRNA#

    0

  9. 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time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529594, encodeId=8794152959434, content=<a href='/topic/show?id=6264e80409d' target=_blank style='color:#2F92EE;'>#细胞迁移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78040, encryptionId=6264e80409d, topicName=细胞迁移)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Apr 05 13:07:59 CST 2020, time=2020-04-05, status=1, ipAttribution=)]
    2020-04-05 医者仁心

    #牙周#

    0

  10. 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    2020-04-05 智智灵药

    #细胞迁移#

    0

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乳腺癌是目前全世界女性中最常见的恶性肿瘤。尽管越来越多的证据表明，长链非编码RNA（lncRNA）在乳腺癌的发生发展过程中起着至关重要的作用，但是大多数lncRNA在乳腺癌中参与的作用目前仍未知晓。同时，越来越多的证据表明，许多lncRNA可以通过竞争性结合一些常见miRNA来充当这些内源性miRNA的海绵。在该研究中，研究人员发现LINC00665可以促进乳腺癌细胞增殖、迁移和侵袭。LINC00

Nat Med：为什么胖了？或许是因为瘦素基因失调

肥胖是一种疾病，影响着全球6.5亿人。当我们看着体重秤上的数字感慨，非常想知道为什么会变胖，为什么我们会比别人更容易胖。科学家们也在试图找出答案。

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