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Diabetes Care:与1型糖尿病病程和血管并发症相关的认知功能缺损!

2018-06-06 xing.T MedSci原创

由此可见,1型糖尿病患者和2型糖尿病患者总体认知能力均明显低于对照组。此外,在50岁以上的1型糖尿病患者中,观察到了并发症与认知之间的关系。虽然两组糖尿病患者表现出相似的赤字模式,但其潜在机制可能不同。当前,1型糖尿病患者的寿命延长,应努力评估认知和识别可改变的行为,以减缓下降。

1型糖尿病患者现在存活时间较长足以经历认知衰退的过程。在中年期间,他们表现出轻度认知缺陷,但严重程度不知道是否会随着年龄的增长而增加或认知功能是否类似于年龄匹配的伴有糖尿病和不伴有糖尿病的同伴。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员对82名50岁以上的1型糖尿病患者、31名年龄匹配的2型糖尿病患者和30名年龄匹配的无糖尿病对照者进行了认知测试和比较。研究人员收集受试者病史和生物标志物,还评估了50岁以上的1型糖尿病患者并发症与认知之间的相关性。

与对照组相比,1型糖尿病患者和2型糖尿病患者在即刻和延迟回忆(P<0.002)和精神运动速度方面表现较差(P<0.01),表现为执行功能较差(P=0.05)。在50岁以上的1型糖尿病患者中,心血管疾病与执行功能减退和增生性糖尿病视网膜病变相关,其运动速度较慢。

由此可见,1型糖尿病患者和2型糖尿病患者总体认知能力均明显低于对照组。此外,在50岁以上的1型糖尿病患者中,观察到了并发症与认知之间的关系。虽然两组糖尿病患者表现出相似的赤字模式,但其潜在机制可能不同。当前,1型糖尿病患者的寿命延长,应努力评估认知和识别可改变的行为,以减缓下降。

原始出处:

Gail Musen,et al. Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications.Diabetes Care.2018. https://doi.org/10.2337/dc17-1955

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    2019-01-18 丁鹏鹏
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    2018-06-06 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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