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Lancet Respir Med:口服泼尼松龙可有效治疗小儿病毒性喘息

2018-01-16 zhangfan MedSci原创

研究认为口服泼尼松龙可有效治疗小儿病毒性喘息,其疗效显著且耐受性好

学龄前儿童病毒性喘息的发病率较高,近日研究人员考察了皮质类固醇治疗小儿病毒性喘息的疗效和安全性。

24-72个月的病毒性喘息患儿参与研究,随机接受口服泼尼松龙(1 mg/kg/d,持续3d)或安慰剂。研究的主要终点为接受治疗到症状消失时间。

624名患儿参与研究,其中605人参与意向性治疗分析,其中安慰剂组300人,泼尼松龙组305人。治疗时间,安慰剂组为540分钟vs泼尼松龙组370分钟。意向分析中,泼尼松龙组治疗的几何平均调整比为0.79(95% CI 0.64-0.97; p=0.0227)。研究过程中未发生严重不良事件,1名安慰剂组患儿出现非特异性的黄斑小叶皮疹,后自行消除。各组均有1名患儿随访期间发生过度兴奋。

研究认为口服泼尼松龙可有效治疗小儿病毒性喘息,其疗效显著且耐受性好。

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    2018-11-14 howi
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    2019-01-01 howi
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    2018-01-16 177200fc66m

    中国基础医师经常用

    0

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    2018-01-16 1ddf0692m34(暂无匿称)

    学习了.涨知识

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    2018-01-16 sunfeifeiyang

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