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JAMA Netw Open:10岁之前胎儿和婴儿的生长模式和大脑形态

2022-01-11 从医路漫漫 MedSci原创

胎儿期和婴儿期是人脑发育的关键时期,在胎儿期,特别是妊娠晚期,大脑有一个快速的增长。皮质灰质和小脑的生长速度在这一时期达到顶峰。出生后第一年,皮质灰质体积增加150%,第二年增加到20%。

背景:胎儿期和婴儿期是人脑发育的关键时期,在胎儿期,特别是妊娠晚期,大脑有一个快速的增长。皮质灰质和小脑的生长速度在这一时期达到顶峰。出生后第一年,皮质灰质体积增加150%,第二年增加到20%。在此期间发生的不良经历可能会永久性地影响大脑结构和功能。目前,支持这一假说的证据主要是基于研究表明,早产或低出生体重的儿童有可能出现神经发育不佳的风险。然而,出生时的胎龄和体重仅仅是胎儿发育的终点和婴儿期的起点。在婴儿期,小胎龄(SGA)、适宜胎龄(AGA)和大胎龄(LGA)出生的儿童有不同的生长模式SGA出生的孩子往往有追赶性生长,而LGA出生的孩子往往有婴儿生长减速。观察性研究表明,婴儿期体重的快速增加与后来的神经认知功能有关,特别是在那些早产儿或SGA出生的人中;然而,对其与脑形态学的关系却知之甚少。基于人口的研究表明,在婴儿时期,体重迅速增加与后来的神经认知功能有关,特别是在早产儿或SGA出生的人中;但对其与脑形态学的关系却知之甚少

目的:探讨学龄期儿童胎儿和婴儿生长发育模式与大脑形态的关系。这项以人群为基础的前瞻性队列研究于2021年2月1日至4月16日进行,作为荷兰鹿特丹一代R研究的一部分。这项研究包括了出生于2002年4月1日至2006年1月31日之间的3098名独生子女。在妊娠的第二和第三个月,通过超声评估胎儿的体重。测量婴儿出生时、6个月、12个月和24个月时的体重。胎儿和婴儿体重加速或减速被定义为两个时间点之间SD评分的变化大于0.67。婴儿的测量还包括峰值体重速度,以及在达到肥胖高峰期的年龄和身体质量指数。

主要结果和测量:大脑结构,包括全大脑和区域的脑容量,在10岁时通过磁共振成像量化。该研究评估了3098名儿童(随访时平均年龄[SD], 10.1[0.6]岁;1557个女孩(50.3%);1753年荷兰语[57.8%])。一项SD评分——妊娠中期和晚期、出生以及6、12和24个月之前体重的增加,与其他任何年龄窗口期的大脑总容量增大无关(妊娠中期:5.7 cm3;95% CI, 1.2-10.2 cm3;晚期妊娠:15.3 cm3;95% CI: 11.0-19.6 cm3;出生:20.8cm3;95% CI: 16.4 ~ 25.1 cm3;6个月:15.6 cm3;95% CI: 11.2-19.9 cm3;12个月:11.3 cm3;95% CI, 7.0-15.6 cm3;24个月:11.1 cm3;95% CI, 6.8-15.4 cm3)。与正常胎儿、婴儿生长发育儿童相比,胎、婴儿生长发育减速儿童的总脑容量最小(-32.5cm3;95% CI, -53.2 - 11.9 cm3)。胎儿体重减速后婴儿追赶生长的儿童与正常生长儿童的脑容量相似。在肥胖高峰时达到的较高的峰值体重速度和体重指数与较大的脑容量有关。在大脑和小脑灰质和白质体积上观察到类似的结果。

表1 出生结果与童年大脑结果的关联

表2 胎儿和婴儿生命关键期与儿童脑部结局

表3 胎儿和婴儿纵向生长模式与儿童脑部结局的关系

表4 婴儿生长模式与儿童大脑发育状况的关系

结果:这项队列研究的结果表明,胎儿和婴儿的体重增长可能对儿童时期的大脑和小脑容量至关重要。这些关联是否与神经认知结果有关还有待进一步研究。

原文出处:

Silva CCV,  El Marroun H,  Sammallahti S,et al.Patterns of Fetal and Infant Growth and Brain Morphology at Age 10 Years.JAMA Netw Open 2021 Dec 01;4(12)

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    2022-02-08 canlab
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    2022-12-06 feather89
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    2022-01-15 ms113193392859020

    学习了,谢谢老师

    0

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    2022-01-14 mrcmqy

    四肢发达头脑简单看来是悖论

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1810397, encodeId=1a27181039ec8, content=<a href='/topic/show?id=66d584848a1' target=_blank style='color:#2F92EE;'>#脑形态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84848, encryptionId=66d584848a1, topicName=脑形态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Wed Sep 21 00:49:56 CST 2022, time=2022-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734456, encodeId=d6611e34456b4, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Tue Feb 08 17:49:56 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729287, encodeId=d71a1e29287b2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 06 15:49:56 CST 2022, time=2022-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184673, encodeId=f21211846e32f, content=学习了,谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a5891777344, createdName=ms113193392859020, createdTime=Sat Jan 15 22:01:37 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184258, encodeId=a4c4118425814, content=四肢发达头脑简单看来是悖论, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210917/4a935e300e70428581ddf5c5a8934007/18969d6c1a16448dae571c9b5f52a52f.jpg, createdBy=1c6d1875332, createdName=mrcmqy, createdTime=Fri Jan 14 16:09:08 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183940, encodeId=501a118394095, content=所以是:有关系,但如何发生关系还需研究?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=97246458534, createdName=ms1000001992064009, createdTime=Thu Jan 13 18:16:20 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183771, encodeId=f8c61183e717a, content=学习了,非常好的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/01/1078d2e0242b103ff542afeb81c7ba21.jpg, createdBy=eb5f5271958, createdName=1354824f40m, createdTime=Thu Jan 13 08:05:52 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183718, encodeId=85f91183e1809, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dee66444401, createdName=ms5000000518050841, createdTime=Thu Jan 13 00:33:07 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183709, encodeId=751c1183e0961, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 12 23:57:59 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183642, encodeId=2c10118364291, content=值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a2e21544432, createdName=7356629, createdTime=Wed Jan 12 20:25:29 CST 2022, time=2022-01-12, status=1, ipAttribution=)]
    2022-01-13 ms1000001992064009

    所以是:有关系,但如何发生关系还需研究?

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1810397, encodeId=1a27181039ec8, content=<a href='/topic/show?id=66d584848a1' target=_blank style='color:#2F92EE;'>#脑形态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84848, encryptionId=66d584848a1, topicName=脑形态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Wed Sep 21 00:49:56 CST 2022, time=2022-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734456, encodeId=d6611e34456b4, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Tue Feb 08 17:49:56 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729287, encodeId=d71a1e29287b2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 06 15:49:56 CST 2022, time=2022-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184673, encodeId=f21211846e32f, content=学习了,谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a5891777344, createdName=ms113193392859020, createdTime=Sat Jan 15 22:01:37 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184258, encodeId=a4c4118425814, content=四肢发达头脑简单看来是悖论, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210917/4a935e300e70428581ddf5c5a8934007/18969d6c1a16448dae571c9b5f52a52f.jpg, createdBy=1c6d1875332, createdName=mrcmqy, createdTime=Fri Jan 14 16:09:08 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183940, encodeId=501a118394095, content=所以是:有关系,但如何发生关系还需研究?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=97246458534, createdName=ms1000001992064009, createdTime=Thu Jan 13 18:16:20 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183771, encodeId=f8c61183e717a, content=学习了,非常好的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/01/1078d2e0242b103ff542afeb81c7ba21.jpg, createdBy=eb5f5271958, createdName=1354824f40m, createdTime=Thu Jan 13 08:05:52 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183718, encodeId=85f91183e1809, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dee66444401, createdName=ms5000000518050841, createdTime=Thu Jan 13 00:33:07 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183709, encodeId=751c1183e0961, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 12 23:57:59 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183642, encodeId=2c10118364291, content=值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a2e21544432, createdName=7356629, createdTime=Wed Jan 12 20:25:29 CST 2022, time=2022-01-12, status=1, ipAttribution=)]
    2022-01-13 1354824f40m

    学习了,非常好的知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1810397, encodeId=1a27181039ec8, content=<a href='/topic/show?id=66d584848a1' target=_blank style='color:#2F92EE;'>#脑形态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84848, encryptionId=66d584848a1, topicName=脑形态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Wed Sep 21 00:49:56 CST 2022, time=2022-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734456, encodeId=d6611e34456b4, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Tue Feb 08 17:49:56 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729287, encodeId=d71a1e29287b2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 06 15:49:56 CST 2022, time=2022-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184673, encodeId=f21211846e32f, content=学习了,谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a5891777344, createdName=ms113193392859020, createdTime=Sat Jan 15 22:01:37 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184258, encodeId=a4c4118425814, content=四肢发达头脑简单看来是悖论, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210917/4a935e300e70428581ddf5c5a8934007/18969d6c1a16448dae571c9b5f52a52f.jpg, createdBy=1c6d1875332, createdName=mrcmqy, createdTime=Fri Jan 14 16:09:08 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183940, encodeId=501a118394095, content=所以是:有关系,但如何发生关系还需研究?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=97246458534, createdName=ms1000001992064009, createdTime=Thu Jan 13 18:16:20 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183771, encodeId=f8c61183e717a, content=学习了,非常好的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/01/1078d2e0242b103ff542afeb81c7ba21.jpg, createdBy=eb5f5271958, createdName=1354824f40m, createdTime=Thu Jan 13 08:05:52 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183718, encodeId=85f91183e1809, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dee66444401, createdName=ms5000000518050841, createdTime=Thu Jan 13 00:33:07 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183709, encodeId=751c1183e0961, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 12 23:57:59 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183642, encodeId=2c10118364291, content=值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a2e21544432, createdName=7356629, createdTime=Wed Jan 12 20:25:29 CST 2022, time=2022-01-12, status=1, ipAttribution=)]
    2022-01-13 ms5000000518050841

    学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1810397, encodeId=1a27181039ec8, content=<a href='/topic/show?id=66d584848a1' target=_blank style='color:#2F92EE;'>#脑形态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84848, encryptionId=66d584848a1, topicName=脑形态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Wed Sep 21 00:49:56 CST 2022, time=2022-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734456, encodeId=d6611e34456b4, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Tue Feb 08 17:49:56 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729287, encodeId=d71a1e29287b2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 06 15:49:56 CST 2022, time=2022-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184673, encodeId=f21211846e32f, content=学习了,谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a5891777344, createdName=ms113193392859020, createdTime=Sat Jan 15 22:01:37 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184258, encodeId=a4c4118425814, content=四肢发达头脑简单看来是悖论, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210917/4a935e300e70428581ddf5c5a8934007/18969d6c1a16448dae571c9b5f52a52f.jpg, createdBy=1c6d1875332, createdName=mrcmqy, createdTime=Fri Jan 14 16:09:08 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183940, encodeId=501a118394095, content=所以是:有关系,但如何发生关系还需研究?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=97246458534, createdName=ms1000001992064009, createdTime=Thu Jan 13 18:16:20 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183771, encodeId=f8c61183e717a, content=学习了,非常好的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/01/1078d2e0242b103ff542afeb81c7ba21.jpg, createdBy=eb5f5271958, createdName=1354824f40m, createdTime=Thu Jan 13 08:05:52 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183718, encodeId=85f91183e1809, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dee66444401, createdName=ms5000000518050841, createdTime=Thu Jan 13 00:33:07 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183709, encodeId=751c1183e0961, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 12 23:57:59 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183642, encodeId=2c10118364291, content=值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a2e21544432, createdName=7356629, createdTime=Wed Jan 12 20:25:29 CST 2022, time=2022-01-12, status=1, ipAttribution=)]
    2022-01-12 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1810397, encodeId=1a27181039ec8, content=<a href='/topic/show?id=66d584848a1' target=_blank style='color:#2F92EE;'>#脑形态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84848, encryptionId=66d584848a1, topicName=脑形态)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Wed Sep 21 00:49:56 CST 2022, time=2022-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734456, encodeId=d6611e34456b4, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Tue Feb 08 17:49:56 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729287, encodeId=d71a1e29287b2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 06 15:49:56 CST 2022, time=2022-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184673, encodeId=f21211846e32f, content=学习了,谢谢老师, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a5891777344, createdName=ms113193392859020, createdTime=Sat Jan 15 22:01:37 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184258, encodeId=a4c4118425814, content=四肢发达头脑简单看来是悖论, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210917/4a935e300e70428581ddf5c5a8934007/18969d6c1a16448dae571c9b5f52a52f.jpg, createdBy=1c6d1875332, createdName=mrcmqy, createdTime=Fri Jan 14 16:09:08 CST 2022, time=2022-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183940, encodeId=501a118394095, content=所以是:有关系,但如何发生关系还需研究?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=97246458534, createdName=ms1000001992064009, createdTime=Thu Jan 13 18:16:20 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183771, encodeId=f8c61183e717a, content=学习了,非常好的知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/01/1078d2e0242b103ff542afeb81c7ba21.jpg, createdBy=eb5f5271958, createdName=1354824f40m, createdTime=Thu Jan 13 08:05:52 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183718, encodeId=85f91183e1809, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dee66444401, createdName=ms5000000518050841, createdTime=Thu Jan 13 00:33:07 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183709, encodeId=751c1183e0961, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 12 23:57:59 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183642, encodeId=2c10118364291, content=值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a2e21544432, createdName=7356629, createdTime=Wed Jan 12 20:25:29 CST 2022, time=2022-01-12, status=1, ipAttribution=)]
    2022-01-12 7356629

    值得拥有

    0

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众所周知,空气污染是众多疾病的罪魁祸首,其中空气中的颗粒物是目前全球面临的重要的污染物之一。

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