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Neurology:脑内微出血增加房颤相关卒中患者死亡率

2014-10-16 幸福的味道 丁香园

近年来有关脑内微出血(CMBs)的研究日益增多,CMB被认为与颅内出血的发生相关。此外,CMB也是记忆门诊患者和老年患者总体死亡率以及心脑血管疾病相关死亡率的独立预测因素。然而,尚不明确CMB与非瓣膜性房颤患者(NVAF)患者长期预后的相关性,因这部分患者常常需要服用抗凝药物治疗,CMB对这部分患者意义更为重大。 为此,来自韩国的学者Ji Hoe Heo等进行了一项研究,旨在明确脑内微出

近年来有关脑内微出血(CMBs)的研究日益增多,CMB被认为与颅内出血的发生相关。此外,CMB也是记忆门诊患者和老年患者总体死亡率以及心脑血管疾病相关死亡率的独立预测因素。然而,尚不明确CMB与非瓣膜性房颤患者(NVAF)患者长期预后的相关性,因这部分患者常常需要服用抗凝药物治疗,CMB对这部分患者意义更为重大。

为此,来自韩国的学者Ji Hoe Heo等进行了一项研究,旨在明确脑内微出血与非瓣膜性房颤患者(NVAF)长期死亡率的相关性,并根据CMB的负担和分布不同来进行分析。CMB的存在和负担与NVAF卒中患者死亡率增加有关。研究发表于最近的Neurology杂志中。

这是一项回顾性的基于医院的观察性研究。共连续入组504例NVAF缺血性卒中患者,均接受大脑T2加权GRE序列磁共振成像。死亡和死亡原因的数据来自韩国国立统计办公室死亡证据。研究旨在明确CMB的负担和分布与全因死亡率,因缺血性心脏病、脑梗、出血性卒中而致的死亡率的相关性。

研究发现,CMB的发生率为30.7%(155/504)。在平均2.5年的随访期内,176例患者(34.9%)死亡,其中缺血性卒中81例;出血性卒中12例;缺血性心脏病32例。伴CMB的患者比那些没有CMB的患者死亡率更高。在校正了年龄、性别、和其他重要变量后发现,存在多个CMB是全因死亡率和缺血性卒中所致死亡率的一个独立的预测因素。严格肺叶内CMB的患者出血性卒中死亡风险增加。

该研究结论认为,CMB的存在和负担与NVAF卒中患者死亡率增加有关。脑叶内CMB的患者的出血性卒中死亡风险增加。CMB的诊断是NVAF卒中患者长期预后的一个有价值的预测因素。

原始出处:

Song TJ1, Kim J1, Song D1, Nam HS1, Kim YD1, Lee HS1, Heo JH2.Association of cerebral microbleeds with mortality in stroke patients having atrial fibrillation.Neurology. 2014 Oct 7;83(15):1308-15. doi: 10.1212/WNL.0000000000000862. Epub 2014 Sep 3.

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    2015-01-03 yinhl1978
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    2014-12-19 rosa00tong

    CMB的存在和负担与NVAF卒中患者死亡率增加有关

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作为健康饮食的一个关键组成部分,医生们常建议人们多食用水果和蔬菜,以来预防慢性疾病。心血管疾病和癌症是全世界死亡的两个主要原因,研究者们不断研究风险因素,减少这些重要疾病的发生,改善健康和长寿。 近年来,虽然已经有越来越多的证据表明,食用水果和蔬菜与死亡率相关,包括心血管疾病和癌症的死亡率,却依然存在争议。一些研究发现,食用水果和蔬菜能降低死亡率的风险,然而研究者观察英国素食者和非素食者

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