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JACC:BNP水平也可预测非心衰患者死亡风险

2018-05-09 MedSci MedSci原创

循环血液中的B型利钠肽(BNP)水平与心衰患者的预后呈强相关,本研究的目的旨在评估BNP水平在心衰患者和非心衰患者中预后的价值。本研究纳入了2002年至2013年数据库中的30487名患者(平均年龄63岁,男性占50%,心衰患者占38%),并对其血浆BNP水平进行了检测,随访时间至2015年。分析结果显示,与心衰患者相比(平均388 pg/ml; 四分位区间: 150 - 940 pg/ml),非

循环血液中的B型利钠肽(BNP)水平与心衰患者的预后呈强相关,本研究的目的旨在评估BNP水平在心衰患者和非心衰患者中预后的价值。本研究纳入了2002年至2013年数据库中的30487名患者(平均年龄63岁,男性占50%,心衰患者占38%),并对其血浆BNP水平进行了检测,随访时间至2015年。分析结果显示,与心衰患者相比(平均388 pg/ml; 四分位区间: 150 - 940 pg/ml),非心衰患者的BNP水平明显更低(平均89 pg/ml; 四分位区间: 34 - 238 pg/ml)(p < 0.0001)。随访期间,5903名非心衰患者(31%)死亡,6181名心衰患者(53%)死亡,经多元分析后发现,BNP水平和年龄与心衰患者和非心衰患者的预后最相关,BNP400 pg/ml与21%心衰患者的3年死亡风险呈相关(95% Cl: 20% - 23%),与19%的非心衰患者3年死亡风险呈相关(95% Cl: 17% - 20%)。研究结果显示,即使在非心衰患者中,血浆BNP水平仍较传统预测因子更能预测患者预后。原始出处:Michelle  K et al.B-

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    2019-03-18 hbwxf
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    2018-05-11 huiwelcome
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