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Stroke:可改变的生活方式与卒中风险

2021-02-05 MedSci原创 MedSci原创

该研究的结果支持了以下假设,受教育程度较低、吸烟和肥胖会增加缺血性卒中、大动脉卒中和小血管卒中的风险,提示改善这些危险因素的生活方式将降低卒中风险。

在规划公共卫生措施时,评估可改变的危险因素是否与卒中风险之间存在因果关系尤为重要,但要从流行病学数据中确定因果关系可能较为困难。近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在评估可改变的生活方式因素,包括教育程度、吸烟和体重指数是否为缺血性卒中及其亚型和出血性卒中的危险因素。

研究人员采用2个样本和多变量孟德尔随机化方法来评估12个生活方式因素对卒中风险的因果效应,以及这些效应是否独立。

研究人员发现遗传预测的受教育年限与缺血性卒中、大动脉卒中和小血管卒中以及脑出血之间呈负相关。基因预测吸烟、体重指数和腰臀比与缺血性卒中和大动脉卒中相关。教育程度、体重指数和吸烟对缺血性卒中的影响是相互独立的。

由此可见,该研究的结果支持了以下假设,受教育程度较低、吸烟和肥胖会增加缺血性卒中、大动脉卒中和小血管卒中的风险,提示改善这些危险因素的生活方式将降低卒中风险。

原始出处:

Eric L. Harshfield.et al.Modifiable Lifestyle Factors and Risk of Stroke A Mendelian Randomization Analysis.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031710

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1281358, encodeId=b182128135883, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Feb 07 11:53:27 CST 2021, time=2021-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=923434, encodeId=1930923434fd, content=受教育程度较低、吸烟和肥胖会增加缺血性卒中、大动脉卒中和小血管卒中的风险!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sun Feb 07 10:33:53 CST 2021, time=2021-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026762, encodeId=f5991026e621b, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Feb 05 23:53:27 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046016, encodeId=a13e1046016b7, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Feb 05 23:53:27 CST 2021, time=2021-02-05, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1281358, encodeId=b182128135883, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Feb 07 11:53:27 CST 2021, time=2021-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=923434, encodeId=1930923434fd, content=受教育程度较低、吸烟和肥胖会增加缺血性卒中、大动脉卒中和小血管卒中的风险!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sun Feb 07 10:33:53 CST 2021, time=2021-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026762, encodeId=f5991026e621b, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Feb 05 23:53:27 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046016, encodeId=a13e1046016b7, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Feb 05 23:53:27 CST 2021, time=2021-02-05, status=1, ipAttribution=)]
    2021-02-07 Jessica

    受教育程度较低、吸烟和肥胖会增加缺血性卒中、大动脉卒中和小血管卒中的风险!

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1281358, encodeId=b182128135883, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Feb 07 11:53:27 CST 2021, time=2021-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=923434, encodeId=1930923434fd, content=受教育程度较低、吸烟和肥胖会增加缺血性卒中、大动脉卒中和小血管卒中的风险!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sun Feb 07 10:33:53 CST 2021, time=2021-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026762, encodeId=f5991026e621b, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Feb 05 23:53:27 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046016, encodeId=a13e1046016b7, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Feb 05 23:53:27 CST 2021, time=2021-02-05, status=1, ipAttribution=)]
    2021-02-05 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1281358, encodeId=b182128135883, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Feb 07 11:53:27 CST 2021, time=2021-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=923434, encodeId=1930923434fd, content=受教育程度较低、吸烟和肥胖会增加缺血性卒中、大动脉卒中和小血管卒中的风险!, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Sun Feb 07 10:33:53 CST 2021, time=2021-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026762, encodeId=f5991026e621b, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Feb 05 23:53:27 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046016, encodeId=a13e1046016b7, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Feb 05 23:53:27 CST 2021, time=2021-02-05, status=1, ipAttribution=)]
    2021-02-05 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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