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Clin Cancer Res:地西他滨联合抗PD-1抗体可有效改善进展/复发性霍奇金淋巴瘤患者预后

2021-03-08 MedSci原创 MedSci原创

单药抗PD-1治疗后复发或进展的慢性粒细胞白血病患者还可采用什么治疗?

程序性死亡蛋白-1(PD-1)阻断单一疗法治疗复发性/难治性经典霍奇金淋巴瘤(cHL)有效,但部分患者会对PD-1抑制剂耐药,仅有少数患者可获得持久的缓解。对于单药抗PD-1治疗后复发或进展的慢性粒细胞白血病患者,迫切需要有效的治疗方案。

在一项测试队列研究中,抗PD-1抗体联合DNA去甲基化药物地西他滨在抗PD-1抗体耐药的患者中已显示出了有效的初步结果。本文报道了在扩展队列中经较长时间随访评估的地西他滨联合抗PD-1治疗的疗效。

总体上,共有51名患者(测试队列:25名,扩展队列:26名)接受了地西他滨联合抗PD-1治疗,其中50名患者被纳入了疗效评估。

抗肿瘤反应

客观有效率在测试队列中为52%(包括9例完全缓解[CR];36%),在扩展队列中为68%(6例CR;24%)。测试队列和扩展队列采用地西他滨联合camrelizumab治疗的患者的中位无进展生存期分别为20.0个月和21.6个月,显著长于既往使用抗PD-1单药治疗所获得的中位无进展生存期。

无进展存活期

在24个月后获得CR的患者中,估计有78%的患者表现为持久的缓解。地西他滨联合camrelizumab治疗后,外周中心记忆T细胞比率的升高与临床疗效和无进展生存期直接相关。

总之,对于PD-1抑制剂治疗失败的复发/难治性慢性粒细胞白血病患者,采用地西他滨联合camrelizumab治疗的缓解率高,且缓解持续时间长。

原始出处:

Wang Chunmeng,Liu Yang,Dong Liang et al. Efficacy of decitabine plus anti-PD-1 camrelizumab in patients with Hodgkin lymphoma who progressed or relapsed after PD-1 blockade monotherapy. Clin Cancer Res, 2021, 10.1158/1078-0432.CCR-21-0133

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    2022-01-13 ms4000000394998932

    题目是霍奇金淋巴瘤,结论怎么是慢性粒细胞白血病?

    0

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  4. 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time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909883, encodeId=a6e1190988340, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Thu Jul 22 00:56:35 CST 2021, time=2021-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1010346, encodeId=0c3610103464c, content=<a href='/topic/show?id=2d4c4140296' target=_blank style='color:#2F92EE;'>#地西他滨#</a>联合<a href='/topic/show?id=9f1b5511901' target=_blank style='color:#2F92EE;'>#抗PD-1#</a>抗体,不仅用于血液肿瘤,可能对很多实体瘤同样适用!!只是具体疗效仍然需要临床验证, beContent=null, objectType=article, channel=null, level=null, likeNumber=203, replyNumber=0, topicName=null, 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createdBy=41e02111625, createdName=1581f8c42cm, createdTime=Tue Mar 09 00:16:10 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946615, encodeId=a14c9466157a, content=进来继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Mon Mar 08 23:37:15 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
    2021-08-22 病毒猎手

    #地西他滨#联合#抗PD-1#抗体,不仅用于血液肿瘤,可能对很多实体瘤同样适用!!只是具体疗效仍然需要临床验证

    0

  5. 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time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909883, encodeId=a6e1190988340, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Thu Jul 22 00:56:35 CST 2021, time=2021-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1010346, encodeId=0c3610103464c, content=<a href='/topic/show?id=2d4c4140296' target=_blank style='color:#2F92EE;'>#地西他滨#</a>联合<a href='/topic/show?id=9f1b5511901' target=_blank style='color:#2F92EE;'>#抗PD-1#</a>抗体,不仅用于血液肿瘤,可能对很多实体瘤同样适用!!只是具体疗效仍然需要临床验证, beContent=null, objectType=article, channel=null, level=null, likeNumber=203, replyNumber=0, topicName=null, 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time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577110, encodeId=38cc15e711070, content=<a href='/topic/show?id=a2a613914cd' target=_blank style='color:#2F92EE;'>#PD-1抗体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13914, encryptionId=a2a613914cd, topicName=PD-1抗体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=021d16387966, createdName=1249857fm37暂无昵称, createdTime=Wed Mar 10 13:56:35 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946623, encodeId=661094662305, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/81d08245657a4a7f9a1ef713c0ec5878/ec4b201a22194a319b1aeb171bc6bb3d.jpg, createdBy=41e02111625, createdName=1581f8c42cm, createdTime=Tue Mar 09 00:16:10 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946615, encodeId=a14c9466157a, content=进来继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Mon Mar 08 23:37:15 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
    2021-07-28 lily81713

    继续学习

    0

  6. 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createdBy=41e02111625, createdName=1581f8c42cm, createdTime=Tue Mar 09 00:16:10 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946615, encodeId=a14c9466157a, content=进来继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Mon Mar 08 23:37:15 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
    2021-03-15 124219b2m20暂无昵称

    学习了

    0

  7. 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time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909883, encodeId=a6e1190988340, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Thu Jul 22 00:56:35 CST 2021, time=2021-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1010346, encodeId=0c3610103464c, content=<a href='/topic/show?id=2d4c4140296' target=_blank style='color:#2F92EE;'>#地西他滨#</a>联合<a href='/topic/show?id=9f1b5511901' target=_blank style='color:#2F92EE;'>#抗PD-1#</a>抗体,不仅用于血液肿瘤,可能对很多实体瘤同样适用!!只是具体疗效仍然需要临床验证, beContent=null, objectType=article, channel=null, level=null, likeNumber=203, replyNumber=0, topicName=null, 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time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577110, encodeId=38cc15e711070, content=<a href='/topic/show?id=a2a613914cd' target=_blank style='color:#2F92EE;'>#PD-1抗体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13914, encryptionId=a2a613914cd, topicName=PD-1抗体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=021d16387966, createdName=1249857fm37暂无昵称, createdTime=Wed Mar 10 13:56:35 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946623, encodeId=661094662305, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/81d08245657a4a7f9a1ef713c0ec5878/ec4b201a22194a319b1aeb171bc6bb3d.jpg, createdBy=41e02111625, createdName=1581f8c42cm, createdTime=Tue Mar 09 00:16:10 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946615, encodeId=a14c9466157a, content=进来继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Mon Mar 08 23:37:15 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
    2021-03-10 科研科研科研

    改善复发性霍奇金淋巴瘤患者预后

    0

  8. 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time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577110, encodeId=38cc15e711070, content=<a href='/topic/show?id=a2a613914cd' target=_blank style='color:#2F92EE;'>#PD-1抗体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13914, encryptionId=a2a613914cd, topicName=PD-1抗体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=021d16387966, createdName=1249857fm37暂无昵称, createdTime=Wed Mar 10 13:56:35 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946623, encodeId=661094662305, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/81d08245657a4a7f9a1ef713c0ec5878/ec4b201a22194a319b1aeb171bc6bb3d.jpg, createdBy=41e02111625, createdName=1581f8c42cm, createdTime=Tue Mar 09 00:16:10 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946615, encodeId=a14c9466157a, content=进来继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Mon Mar 08 23:37:15 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
  9. 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time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577110, encodeId=38cc15e711070, content=<a href='/topic/show?id=a2a613914cd' target=_blank style='color:#2F92EE;'>#PD-1抗体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13914, encryptionId=a2a613914cd, topicName=PD-1抗体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=021d16387966, createdName=1249857fm37暂无昵称, createdTime=Wed Mar 10 13:56:35 CST 2021, time=2021-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946623, encodeId=661094662305, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200814/81d08245657a4a7f9a1ef713c0ec5878/ec4b201a22194a319b1aeb171bc6bb3d.jpg, createdBy=41e02111625, createdName=1581f8c42cm, createdTime=Tue Mar 09 00:16:10 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946615, encodeId=a14c9466157a, content=进来继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Mon Mar 08 23:37:15 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
    2021-03-09 1581f8c42cm

    学习

    0

  10. 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