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Prostate Cancer P D: 前列腺癌SLCO基因表达与格林森等级和雄激素阻断治疗后变化相关性分析

2019-04-04 AlexYang MedSci原创

雄激素阻断治疗(ADT)后,SLCO编码的转运蛋白与去势难治性前列腺癌(CRPC)的恶化相关。尽管比CRPC组织中的表达水平更低,SLCO编码的转运蛋白可能在原发性前列腺癌(PCa)对ADT和生化复发响应中具有作用。最近,有研究人员系统性的探索了11个人类SLCO基因的表达在正常的前列腺(NP)和ADT治疗和未治疗的原发性PCa组织中的表达情况,包括了阿比特龙新辅助治疗的肿瘤。研究发现,在PCa中

雄激素阻断治疗(ADT)后,SLCO编码的转运蛋白与去势难治性前列腺癌(CRPC)的恶化相关。尽管比CRPC组织中的表达水平更低,SLCO编码的转运蛋白可能在原发性前列腺癌(PCa)对ADT和生化复发响应中具有作用。

最近,有研究人员系统性的探索了11个人类SLCO基因的表达在正常的前列腺(NP)和ADT治疗和未治疗的原发性PCa组织中的表达情况,包括了阿比特龙新辅助治疗的肿瘤。研究发现,在PCa中检测到了转运蛋白最常见的类固醇吸收的作用,包括了原发性PCa中的SLCO2B1 (DHEAS)和1B3 (睾丸素)。SLCO1B3的表达水平在PCa中将近NP的5倍,并且在格林森等级3和4之间没有差异,ADT治疗后也没有发生变化。SLCO2B1的表达水平比NP低3倍,但是在格林森等级4中比格林森等级3要高出将近7倍,并且在ADT治疗后增加将近3倍(p<0.05)。

最后,研究人员指出,他们在PCa和NP样本、格林森等级4和等级3肿瘤以及ADT治疗和未治疗的组织中观察到了SLCO表达的明显差异。他们的发现虽然是基于小样本,但是基线和ADT诱导的PCa中OATP变化可能对固醇类吸收和ADT响应具有影响,以及治疗的药物的影响,包括阿比特龙和多烯紫杉醇。

原始出处:

Mazen Alsinnawi, Ailin Zhang, Daniella Bianchi-Frias et al. Association of prostate cancer SLCO gene expression with Gleason grade and alterations following androgen deprivation therapy. Prostate Cancer P D. 19 Mar 2019.

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time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040429, encodeId=6ed9104042952, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Apr 04 15:44:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1837667, encodeId=3b2d183e667b0, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Oct 04 04:44:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710184, encodeId=8b3f1e10184b8, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, 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time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040429, encodeId=6ed9104042952, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Apr 04 15:44:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1837667, encodeId=3b2d183e667b0, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Oct 04 04:44:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710184, encodeId=8b3f1e10184b8, content=<a href='/topic/show?id=7ac59e67604' target=_blank style='color:#2F92EE;'>#阻断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97676, encryptionId=7ac59e67604, topicName=阻断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5ca31824852, 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href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Sat Apr 06 03:44:00 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602142, encodeId=e53116021428e, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sat Apr 06 03:44:00 CST 2019, time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040429, encodeId=6ed9104042952, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Apr 04 15:44:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
    2019-04-06 lsndxfj
  7. 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  8. 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  9. 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time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040429, encodeId=6ed9104042952, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Apr 04 15:44:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
    2019-04-06 sunylz
  10. 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time=2019-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040429, encodeId=6ed9104042952, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Apr 04 15:44:00 CST 2019, time=2019-04-04, status=1, ipAttribution=)]
    2019-04-04 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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盘点:前列腺癌与相关机制

【1】Nucleic Acids Res:揭示长链非编码RNA PCAT1促进去势抵抗性前列腺癌进展的新机制 http://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz108/5324447在PTEN缺失的前列腺癌中,AKT信号通路的激活依赖于雄激素受体信号通路的抑制。HLPP/FKBP51/IKKα蛋白复合体在AKT和NF-

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