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Sci Transl Med:寨卡病毒的近亲对胎儿的影响

2018-02-05 药明康德 学术经纬

寨卡病毒 (Zika Virus) 虽然在半个世纪前就被发现,但是它对受到感染的孕妇体内胎儿的影响最近才被确认。

寨卡病毒 (Zika Virus) 虽然在半个世纪前就被发现,但是它对受到感染的孕妇体内胎儿的影响最近才被确认。寨卡病毒感染孕妇能够造成胎盘损伤,胎儿生长受限,小头畸形和胎儿死亡。华盛顿大学 (Washington University) 医学院的研究人员发现,西尼罗河病毒 (West Nile Virus) 和Powassan病毒在小鼠模型中同样可以感染胚胎并且造成胚胎死亡。这两种病毒同属于嗜神经黄病毒 (neurotropic flaviviruses) 。研究人员同时发现这两种病毒也可以在人类母体和胎儿外植体组织中复制增生。这项研究表明,其它新兴嗜神经黄病毒可能与寨卡病毒一样能够跨越胎盘感染胎儿,并且在正在发育的胎儿身上造成损伤。我们需要更加关注对这些病毒在人群中的传播。

原始出处:

Derek J. Platt,et al.Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice.Sci Transl Med.31 Jan 2018:Vol. 10, Issue 426, eaao7090.

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