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Scientific Reports:破解胆结石形成机制

2018-09-03 佚名 新华网

一项国际研究发现,胆结石的形成与特定细菌的基因有关。研究人员认为,这一发现有助于开发胆结石治疗新方法,降低胆结石手术的必要性。


一项国际研究发现,胆结石的形成与特定细菌的基因有关。研究人员认为,这一发现有助于开发胆结石治疗新方法,降低胆结石手术的必要性。

此前科学界已经发现克雷伯氏菌等细菌与胆结石的形成存在关联,但尚不清楚这些细菌在人类胆囊中生存并致病的机制。

澳大利亚柯廷大学研究人员与国际同行一起,在新一期英国《科学报告》杂志上报告了新发现。他们将细菌基因组和胆固醇结合起来分析,详细研究了人类胆结石的细菌构成和基因作用。

新研究确认了多种与胆结石有关的细菌基因,这些基因能帮助克雷伯氏菌等细菌在表面形成一层保护性的生物膜。这种生物膜不仅让细菌能抵御抗生素等药物,有机会在胆囊中生存下来,还能起到“胶水”一样的作用,使细菌不断积聚,这可能是胆结石形成的关键因素。

研究论文的主要作者、柯廷大学研究人员叙雷亚·柯塞说,新研究有助于了解胆囊中细菌生存和导致胆结石产生的机制,并据此进一步开发出除手术以外的疗法,减轻患者痛苦。

原始出处:

S. H. Kose,et al.Metagenomics of pigmented and cholesterol gallstones: the putative role of bacteria.Scientific Reportsvolume 8, Article number: 11218 (2018) 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=349520, encodeId=6e3c3495206b, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5222246865, createdName=121578c9m66(暂无昵称), createdTime=Tue Oct 16 11:19:35 CST 2018, time=2018-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344108, encodeId=39a5344108d2, content=原来如此, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRqgE6xZ8YaH0qaiaLKtuWxbvvEqX8qgSGfkiavaHP6tuo3qpnUefo1gK4oQdnKPjMdSQX6IchZ1ib2s/0, createdBy=317b1661419, createdName=反正, createdTime=Sun Sep 09 07:52:29 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375859, encodeId=5e9613e585979, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Wed Sep 05 11:51:00 CST 2018, time=2018-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342498, encodeId=38aa34249856, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Mon Sep 03 21:22:20 CST 2018, time=2018-09-03, status=1, ipAttribution=)]
    2018-09-09 反正

    原来如此

    0

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    2018-09-05 jichang
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    2018-09-03 医者仁心5538

    学习了

    0

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