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JACC:房颤患者认知功能的降低与亚临床脑损伤相关

2019-03-12 不详 MedSci原创

房颤患者发生认知功能下降的风险更高,可能是由未知的脑血管损伤引起。本研究的目的旨在评估房颤患者的认知功能和脑血管损伤的相关性。本研究纳入了1737名房颤患者,平均年龄为73 ± 8 岁,女性占28%,90%接受有口服抗凝药物治疗。经过头颅磁共振检查,发现387名(22%)患者有大的非皮质或皮质梗塞(LNCCIs),368名(21%)患者有皮质下小梗死(SNCIs),372名(22%)患者有微出血,

房颤患者发生认知功能下降的风险更高,可能是由未知的脑血管损伤引起。本研究的目的旨在评估房颤患者的认知功能和脑血管损伤的相关性。

本研究纳入了1737名房颤患者,平均年龄为73 ± 8 岁,女性占28%,90%接受有口服抗凝药物治疗。经过头颅磁共振检查,发现387名(22%)患者有大的非皮质或皮质梗塞(LNCCIs),368名(21%)患者有皮质下小梗死(SNCIs),372名(22%)患者有微出血,1715名(99%)患者有白质病变。蒙特利尔认知评估量表(MoCA)评分在有SNCIs和没有SNCIs的患者中分别是24.7 ± 3.3和25.8 ± 2.9(p < 0.001)。另外,LNCCIs的面积是MoCA评分降低的最强预测因素。

研究结果显示,房颤患者的大脑梗塞风险明显更高,患有其他脑损伤的风险也更高,且大部分损伤是没有直接临床症状的,这些与房颤患者的认知功能降低相关。

原始出处:

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    2019-04-28 hbwxf
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    2019-03-13 smartxiuxiu

    0

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    2019-03-12 jingjing

    大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等

    0

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