Trends in Biochemical Sciences (TiBS) is designed to keep its readers up-to-date and well informed about recent advances in biochemistry and molecular biology. In addition to topical reviews, which provide the main focus of each issue, TiBS provides a platform for debate and hypothesis where new ideas can be discussed. A popular section is the Protein Sequence Motif column, which publishes short reports of new motifs or sequence homologies that have been recognised in known sequences. TiBS also features letters, reviews of computer applications and techniques, historical perspectives of biochemical and molecular biology research, and book reviews.