期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
We evaluated the effects of dentine biomodification after pre-treatment with two sulphonamide carbonic anhydrase inhibitors (CAIs) of the N-[4-sulpham......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
A series of 1,2,3-benzoxathiazine-2,2-dioxides possessing various substituents in the 5, 7, or 8 position was obtained from corresponding 2-hydroxyben......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
Click chemistry reactions constitute an important and relatively new approach in the medicinal chemistry toolbox and offer substantial advantages to m......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
This study does not propose to elucidate how adiponectin secretion is regulated, but how its adiponectin concentration is an indicator of heart diseas......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
The increasing resistance of fungi to conventional antifungal drugs has prompted worldwide the search for new compounds. In this work, we investigated......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
Structural tailoring of the flavone framework (position 7) via organopalladium-catalyzed C-C bond formation was attempted in this study. The impact of......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
A library of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates was synthesised by selective S-alkylation of the easily accessible 4-thioureid......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
Androgen deprivation therapy (ADT) is a common treatment for recurrent prostate cancer (PC). However, after a certain period of responsiveness, ADT re......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy. Numerous antibiotics could interact with biologically relevant macromolec......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
A series of 6-ureido/amidocoumarins (5a-p and 7a-c) has been designed and synthesised to develop potent and isoform- selective carbonic anhydrase hCA ......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulat......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
Schizophrenia is a chronic mental disorder that is not satisfactorily treated with available antipsychotics. The presented study focuses on the search......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
A novel library of human carbonic anhydrase (hCA) inhibitors based on the 2-sulfanilamido[1,2,4]triazolo[1,5-a]pyrimidine skeleton modified at its 7-p......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
A chromone-peptidyl hybrids series was synthesised and rationally repurposed towards identification of potential antileishmanial hits against visceral......
期刊： JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023; 38 (1)
New quinoline-pyridine hybrids were designed and synthesised as PIM-1/2 kinase inhibitors. Compounds 5b, 5c, 6e, 13a, 13c, and 14a showed in-vitro low......
